Evidence map›Paper›PMID 29515217›Full record

ArticleEye (London, England)2018

B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model.

Gaoqin Liu, Peirong Lu, Lei Chen, Wenpeng Zhang, Mengjiao Wang, Dan Li, Xueguang Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gaoqin LiuDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Peirong LuDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou, China. lupeirong@suda.edu.cn.ORCID http://orcid.org/0000-0002-1423-1737
Lei ChenDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Wenpeng ZhangDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Mengjiao WangDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Dan LiDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Xueguang ZhangJiangsu Key Laboratory of Clinical Immunology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCorneal neovascularization (CrNV) arises from many causes including corneal inflammatory, infectious, or traumatic insult, and frequently leads to impaired vision. This study seeks to determine the role of B-cell leukemia/lymphoma 10 (BCL-10) in the development of experimental CrNV.

methodsCorneas from BCL-10 knockout (KO) mice and wild-type (WT) mice were burned by sodium hydroxide (NaOH) to create the CrNV model and neovascular formation in the corneas was assessed 2 weeks later. Intracorneal macrophage accumulation and the expression of angiogenic factors were quantified by flow cytometric analysis (FCM) and real-time PCR, respectively.

resultsThe amount of CrNV was determined 2 weeks after alkali burn. Compared to WT mice, the amount of CrNV in BCL-10 KO mice was significantly decreased. FCM revealed that F4/80-positive macrophages were markedly decreased in BCL-10 KO mice compared with WT mice. Reverse transcription PCR showed that the mRNA expression levels of intracorneal vascular endothelial growth factor-A (VEGF-A), basic fibroblast growth factor (bFGF) and monocyte chemotactic protein 1 were reduced in BCL-10 KO mice compared with WT mice.

conclusionBCL-10 KO mice exhibited reduced alkali-induced CrNV by suppressing intracorneal macrophage infiltration, which subsequently led to decreased VEGF-A and bFGF expression, suggesting that BCL-10 may become a potential clinical intervening target of CrNV.

Indexed as

AnimalsB-Cell CLL-Lymphoma 10 ProteinBurns, ChemicalCorneal NeovascularizationDisease Models, AnimalFibroblast Growth FactorsMacrophagesMiceMice, Inbred BALB CMonocyte Chemoattractant ProteinsReal-Time Polymerase Chain ReactionRNA, MessengerVascular Endothelial Growth Factor AB-Cell CLL-Lymphoma 10 ProteinFibroblast Growth FactorsMonocyte Chemoattractant ProteinsRNA, MessengerVascular Endothelial Growth Factor A

Identifiers

PMID29515217
PMCPMC6043546
OpenAlexW2791705505

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.