Trial reportScientific reports2018
Biological Age is a predictor of mortality in Ischemic Stroke.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy.GeroScience · 2026Pooled it
- Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.Clinical epigenetics · 2022Pooled it
- Associations of Biological Age and Heart Age Accelerations With New-Onset Stroke in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From a Chinese Longitudinal Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- DNA Methylation-Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms.Brain and behavior · 2026Article
- Epigenetic age acceleration in young adults with congenital heart disease.Clinical epigenetics · 2026Article
- The Relevance of Chronological and Biological Aging in the Progression of Multiple Sclerosis.Healthcare (Basel, Switzerland) · 2025Review
- Association of biological age acceleration with poor outcome after endovascular thrombectomy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Does the southern health disadvantage extend to accelerated biological aging: evidence from the health and retirement study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Association of phenotypic age and accelerated aging with severity and disability in patients with acute ischemic stroke.The journal of nutrition, health & aging · 2024Article
- Hemorrhagic stroke and atherogenic markers - is there any relation?Journal of family medicine and primary care · 2024Article
- Ischemic Stroke and the Biological Hallmarks of Aging.Aging and disease · 2024Review
- Article
- Long Non-Coding H19 in Lymphocytes: Prognostic Value in Acute Ischemic Stroke Patients.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants.BMC public health · 2024Article
- The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review.International journal of molecular sciences · 2024Review
- Machine Learning Approximations to Predict Epigenetic Age Acceleration in Stroke Patients.International journal of molecular sciences · 2023Article
- Association betweenFrontiers in neurology · 2023Article
- Article
- Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.Biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across the genome can be used to estimate biological age, which is influenced by lifestyle, environmental factors, and genetic variation. We analyzed the impact of biological age on 3-month mortality in ischemic stroke. We assessed 594 patients with acute ischemic stroke in a cohort from Hospital del Mar (Barcelona) and validated the results in an independent cohort. Demographic and clinical data, including chronological age, vascular risk factors, initial stroke severity (NIHSS score), recanalization treatment, and previous modified Rankin scale were registered. Biological age was estimated with an algorithm based on DNA methylation in 71 CpGs. Biological age was predictive of 3-month mortality (p = 0.041; OR = 1.05, 95% CI 1.00-1.10), independently of NIHSS score, chronological age, TOAST, vascular risk factors, and blood cell composition. Stratified by TOAST classification, biological age was associated with mortality only in large-artery atherosclerosis etiology (p = 0.004; OR = 1.14, 95% CI 1.04-1.25). As estimated by DNA methylation, biological age is an independent predictor of 3-month mortality in ischemic stroke regardless of chronological age, NIHSS, previous modified Rankin scale, and vascular risk factors.
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