ArticleScientific reports2018
Capillary flow homogenization during functional activation revealed by optical coherence tomography angiography based capillary velocimetry.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas.Nature communications · 2026Article
- Microcirculatory failure after successful recanalization in ischemic stroke: insights into mechanisms, imaging, and therapeutic strategies.Frontiers in pharmacology · 2026Review
- Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia.Stroke · 2023Review
- Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.Scientific reports · 2023Article
- Endothelial structure contributes to heterogeneity in brain capillary diameter.Vascular biology (Bristol, England) · 2023Article
- Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure.Nature communications · 2022Article
- A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMROJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- A versatile toolbox for studying cortical physiology in primates.Cell reports methods · 2022Article
- Pericyte Control of Blood Flow Across Microvascular Zones in the Central Nervous System.Annual review of physiology · 2022Review
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Brain capillary pericytes exert a substantial but slow influence on blood flow.Nature neuroscience · 2021Article
- VasoMetrics: unbiased spatiotemporal analysis of microvascular diameter in multi-photon imaging applications.Quantitative imaging in medicine and surgery · 2021Article
- Automated vessel diameter quantification and vessel tracing for OCT angiography.Journal of biophotonics · 2020Article
- Validation of red blood cell flux and velocity estimations based on optical coherence tomography intensity fluctuations.Scientific reports · 2020Article
- Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation.Journal of biomedical optics · 2020Article
- Procedure and protocols for optical imaging of cerebral blood flow and hemodynamics in awake mice.Biomedical optics express · 2020Article
- Optical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study.Scientific reports · 2020Article
- Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography.Biomedical optics express · 2020Article
- Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice.Optics letters · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Elaborate modeling study suggests an important role of capillary transit time heterogeneity (CTTH) reduction in brain oxygenation during functional hyperemia. Here, we use optical coherence tomography angiography (OCTA) capillary velocimetry to probe blood flow dynamics in cerebral capillary beds and validate the change in CTTH during functional activation in an in vivo rodent model. Through evaluating flow dynamics and consequent transit time parameters from thousands of capillary vessels within three-dimensional (3-D) tissue volume upon hindpaw electrical stimulation, we observe reductions in both capillary mean transit time (MTT) (9.8% ± 2.2) and CTTH (5.9% ± 1.4) in the hindlimb somatosensory cortex (HLS1). Additionally, capillary flow pattern modification is observed with a significant difference (p < 0.05) between the HLS1 and non-activated cortex regions. These quantitative findings reveal a localized microcirculatory adjustment during functional activation, consistent with previous studies, and support the critical contribution of capillary flow homogenization to brain oxygenation. The OCTA velocimetry is a useful tool to image microcirculatory dynamics in vivo using animal models, enabling a more comprehensive understanding as to hemodynamic-metabolic coupling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.