Evidence map›Paper›PMID 29515153›Full record

ArticleScientific reports2018

Down-regulation of GADD45A enhances chemosensitivity in melanoma.

Jia Liu, Guoqiang Jiang, Ping Mao, Jing Zhang, Lin Zhang, Likun Liu, Jia Wang, Lawrence Owusu, Baoyin Ren, Yawei Tang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Military Medical Research · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Frontiers in endocrinology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Roles for GADD45 in Development and Cancer.Advances in experimental medicine and biology · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Deuterium Oxide (DCancers · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jia LiuDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China.
Guoqiang JiangDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China.
Ping MaoDepartment of General Surgery, The people's Hospital of Liaoning Province, Shenyang, 110016, Liaoning, China.
Jing ZhangDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China.
Lin ZhangAcademy of Integrative Medicine, Dalian Medical University, Dalian, 116044, China.
Likun LiuDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China.
Jia WangDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China.
Lawrence OwusuDepartment of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Baoyin RenDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China.
Yawei TangDepartment of Immunology, Dalian Medical University, Dalian, 116044, China.
Weiling LiDepartment of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning, China. liweiling2015@163.com.
Dalian Medical University · CNKwame Nkrumah University of Science and Technology · GHLiaoning Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is a malignant skin cancer with considerable drug resistance. Increased expression of DNA repair genes have been reported in melanoma, and this contributes to chemotherapy resistance. GADD45A is involved in DNA repair, cell cycle arrest and apoptosis in response to physiologic or environmental stresses. In this study, we investigated the role of GADD45A in chemotherapy response. Firstly, the mRNA expression of profiled DNA repair genes in cisplatin-treated melanoma cells was detected by RT

Indexed as

MelanomaApoptosisCell Cycle ProteinsCell Line, TumorCisplatinDown-RegulationDrug Resistance, NeoplasmG2 Phase Cell Cycle CheckpointsGADD45 ProteinsGene Expression Regulation, NeoplasticHumansM Phase Cell Cycle CheckpointsNeoplasm ProteinsNuclear ProteinsCell Cycle ProteinsCisplatinGADD45A protein, humanGADD45 ProteinsNeoplasm ProteinsNuclear Proteins

Identifiers

PMID29515153
PMCPMC5841426
OpenAlexW2805518785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.