Trial reportScientific reports2018
Multidimensional impulsivity as a mediator of early life stress and alcohol dependence.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A Systematic Review of the Balloon Analogue Risk Task (BART) in Alcohol Research.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Pooled it
- Combined maternal separation and limited bedding-nesting increase goal tracking, delay discounting, and impulsive action, and moderate sign-tracking-perseverance associations in male rats.BMC neuroscience · 2026Article
- Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.Neurobiology of stress · 2025Article
- Patient, supporter and primary healthcare professional perspectives on health risks in over 16s with attention deficit hyperactivity disorder (ADHD) in England: a national survey study.BMC health services research · 2024Article
- Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.Addiction neuroscience · 2023Article
- Changes in Electroencephalography Alpha Associated With Childhood Neglect and Adolescent Alcohol Use.Child maltreatment · 2023Article
- Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA): methods and design of a randomized laboratory study.BMC psychology · 2022Article
- The effects of early life stress on impulsivity.Neuroscience and biobehavioral reviews · 2022Review
- Early life stress and substance use disorders: The critical role of adolescent substance use.Pharmacology, biochemistry, and behavior · 2022Review
- Do Trajectories of Sensation Seeking Vary by Sex and Child Maltreatment Subtypes?Journal of interpersonal violence · 2022Article
- Alcohol Use and Gambling Associated with Impulsivity among a Swedish University Sample.International journal of environmental research and public health · 2022Article
- Externalizing personality characteristics define clinically relevant subgroups of alcohol use disorder.PloS one · 2022Article
- Cumulative lifetime stress exposure predicts greater impulsivity and addictive behaviors.Journal of health psychology · 2021Article
- Interrelationships among whole-body skeletal muscle mass, masseter muscle mass, oral function, and dentition status in older Japanese adults.BMC geriatrics · 2021Article
- The Development of Externalizing and Internalizing Behaviors Among Youth With or Without a Family History of Substance Use Disorder: The Indirect Effects of Early-Life Stress and Impulsivity.Child psychiatry and human development · 2021Article
- Impulsivity mediates the impact of early life adversity on high risk behaviors among Tunisian adolescents.Preventive medicine reports · 2021Article
- Childhood psychopathology mediates associations between childhood adversities and multiple health risk behaviours in adolescence: analysis using the ALSPAC birth cohort.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Impulsivity Scale-12 and its utilization in alcohol use disorder.Drug and alcohol dependence · 2021Article
- Consistent evidence of indirect effects of impulsive delay discounting and negative urgency between childhood adversity and adult substance use in two samples.Psychopharmacology · 2021Article
- The 21-item Barratt Impulsiveness Scale Revised (BIS-R-21): An alternative three-factor model.Journal of behavioral addictions · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life stress (ELS) leads to increased susceptibility to serious psychiatric problems such as alcohol dependence, but the mechanisms through which ELS affects alcohol dependence are unclear. We investigated the mediating role of multi-dimensional impulsivity in the associations between ELS and alcohol dependence. 330 male patients with alcohol dependence (mean age = 48.39) completed self-rating scales of ELS and several self-report measures of impulsivity as well as balloon analogue risk task (BART). After classifying different dimensions of impulsivity using factor analysis, structural equation modeling was conducted to test the mediation effects of impulsivity between ELS and alcohol dependence severity and social onset of hazardous drinking. Among the participants, 64.8%, 42.1% and 47.9% reported at least one episode of childhood maltreatment, sexual abuse and parental conflict, respectively. Response impulsivity-sensation seeking, reflection impulsivity and aggression partially mediated the association between ELS and severity of alcohol dependence (CFI = 0.902 and RMSEA = 0.079). Reflection impulsivity dimension partially mediated the association between ELS and social onset of hazardous drinking (CFI = 0.939, RMSEA = 0.091). These finding imply that stabilizing vulnerabilities such as reflection impulsivity via intervention programs that target young individuals with ELS may be helpful in delaying the onset of hazardous drinking and prevent alcohol dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.