Evidence map›Paper›PMID 29515128›Full record

ArticleScientific reports2018

The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.

J J Nieto-Fontarigo, F J Salgado, M E San-José, M J Cruz, A Casas-Fernández, M J Gómez-Conde, L Valdés-Cuadrado, M Á García-González, P Arias, M Nogueira and 1 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Gene polymorphisms in asthma: a narrative review.Annals of translational medicine · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

J J Nieto-FontarigoDepartment of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
F J SalgadoDepartment of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain. franciscojavier.salgado@usc.es.
M E San-JoséClinical Analysis Service, University Hospital of Santiago de Compostela (CHUS), Santiago de Compostela, Spain.
M J CruzDepartment of Respiratory Medicine-Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
A Casas-FernándezClinical Analysis Service, University Hospital of Santiago de Compostela (CHUS), Santiago de Compostela, Spain.
M J Gómez-CondeClinical Analysis Service, University Hospital of Santiago de Compostela (CHUS), Santiago de Compostela, Spain.
L Valdés-CuadradoDepartment of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
M Á García-GonzálezHealth Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
P AriasDepartment of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
M NogueiraDepartment of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
F J González-BarcalaSpanish Biomedical Research Networking Centre-CIBERES, Santiago de Compostela, Spain.ORCID 0000-0001-5847-4784
Universidade de Santiago de Compostela · ESInstituto de Investigación Sanitaria de Santiago · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH

Indexed as

Polymorphism, Single NucleotideAdultAsthmaBiomarkersCase-Control StudiesFemaleGene Expression RegulationHumansLeukocyte CountLipopolysaccharide ReceptorsMaleMiddle AgedMonocytesBiomarkersCD14 protein, humanLipopolysaccharide Receptors

Identifiers

PMID29515128
PMCPMC5841440
OpenAlexW2796925401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.