ArticleJournal of the Royal Society, Interface2017
Switches induced by quorum sensing in a model of enzyme-loaded microparticles.
Article in Journal of the Royal Society, Interface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Quorum Sensing in Emulsion Droplet Swarms Driven by a Surfactant Competition System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- Feedback and Communication in Active Hydrogel Spheres with pH Fronts: Facile Approaches to Grow Soft Hydrogel Structures.Angewandte Chemie (International ed. in English) · 2021Article
- Reaction-diffusion hydrogels from urease enzyme particles for patterned coatings.Communications chemistry · 2021Article
- Viewpoint: From Responsive to Adaptive and Interactive Materials and Materials Systems: A Roadmap.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- Modelling Bacteria-Inspired Dynamics with Networks of Interacting Chemicals.Life (Basel, Switzerland) · 2019Article
- Immobilization adjusted clock reaction in the urea-urease-HRSC advances · 2019Article
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Authors and funding
2 authors.
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Abstract
Quorum sensing refers to the ability of bacteria and other single-celled organisms to respond to changes in cell density or number with population-wide changes in behaviour. Here, simulations were performed to investigate quorum sensing in groups of diffusively coupled enzyme microparticles using a well-characterized autocatalytic reaction which raises the pH of the medium: hydrolysis of urea by urease. The enzyme urease is found in both plants and microorganisms, and has been widely exploited in engineering processes. We demonstrate how increases in group size can be used to achieve a sigmoidal switch in pH at high enzyme loading, oscillations in pH at intermediate enzyme loading and a bistable, hysteretic switch at low enzyme loading. Thus, quorum sensing can be exploited to obtain different types of response in the same system, depending on the enzyme concentration. The implications for microorganisms in colonies are discussed, and the results could help in the design of synthetic quorum sensing for biotechnology applications such as drug delivery.
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