Evidence map›Paper›PMID 29514977›Full record

ArticleThe Journal of biological chemistry2018

The HUS box is required for allosteric regulation of the Sec7 Arf-GEF.

Steve L Halaby, J Christopher Fromme

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Sec7 regulatory domains scaffold autoinhibited and active conformations.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Arf1 orchestrates Rab GTPase conversion at theMolecular biology of the cell · 2021
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Steve L HalabyFrom the Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853.
J Christopher FrommeFrom the Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853 jcf14@cornell.edu.
Cornell University · US

Funding

PREDOCTORAL TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM007273 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BRETSCHER, ANTHONY P. · 1985 to 2019
$11.6M
Regulation of Arf GTPase activation at the trans-Golgi networkR01GM098621 · NIGMS · CORNELL UNIVERSITY · PI FROMME, J CHRISTOPHER · 2012 to 2020
$2.9M
NIGMS NIH HHS R01 GM098621NIGMS NIH HHS T32 GM007273
6 · The paper itself

Abstract

The Golgi complex is the central membrane and protein-sorting station in eukaryotic cells. Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adaptors and coat proteins necessary for Golgi trafficking. Arf activation is spatially and temporally regulated by distinct guanine nucleotide exchange factors (GEFs) at different Golgi compartments. The yeast Arf-GEF Sec7 is a conserved and essential activator of Arf1 at the

Indexed as

ADP-Ribosylation FactorsAllosteric RegulationCatalytic DomainEnzyme ActivationGolgi ApparatusGuanine Nucleotide Exchange FactorsModels, MolecularMutationProtein BindingProtein MultimerizationProtein Transportrab GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidADP-Ribosylation FactorsGuanine Nucleotide Exchange Factorsrab GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsSec7 guanine nucleotide exchange factorsYPT31 protein, S cerevisiaeADP ribosylation factor (ARF)allosteric regulationGolgiGTPaseguanine nucleotide exchange factor (GEF)intracellular trafficking

Identifiers

PMID29514977
PMCPMC5936818
OpenAlexW2792954723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.