Evidence map›Paper›PMID 29514976›Full record

ArticleThe Journal of biological chemistry2018

Functional roles of the DNA-binding HMGB domain in the histone chaperone FACT in nucleosome reorganization.

Laura L McCullough, Zaily Connell, Hua Xin, Vasily M Studitsky, Alexey V Feofanov, Maria E Valieva, Tim Formosa

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Beyond Chaperoning: The Multifaceted Role of FACT in Chromatin Transactions.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. R-Loops and Its Chro-Mates: The Strange Case of Dr. Jekyll and Mr. Hyde.International journal of molecular sciences · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Overexpression ofFrontiers in plant science · 2020
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Laura L McCulloughFrom the Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132.
Zaily ConnellFrom the Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132.
Hua XinFrom the Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132.
Vasily M Studitskythe Biology Faculty, Lomonosov, Moscow State University, Leninskie Gory 1, Moscow 119992, Russia.
Alexey V Feofanovthe Biology Faculty, Lomonosov, Moscow State University, Leninskie Gory 1, Moscow 119992, Russia.
Maria E Valievathe Biology Faculty, Lomonosov, Moscow State University, Leninskie Gory 1, Moscow 119992, Russia.
Tim FormosaFrom the Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132, tim@biochem.utah.edu.
University of Utah · USFox Chase Cancer Center · USInstitute of Bioorganic Chemistry · RULomonosov Moscow State University · RU

Funding

Biochemical, Genetic, and Genomic Analysis of Nucleosome Reorganization by FACTR01GM064649 · NIGMS · UNIVERSITY OF UTAH · PI FORMOSA, TIMOTHY G · 2002 to 2022
$6.4M
Mechanism of yFACT Action during Chromatin TranscriptionR01GM119398 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI STILLMAN, DAVID J, STUDITSKY, VASILY M · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM064649NIGMS NIH HHS R01 GM119398
6 · The paper itself

Abstract

The essential histone chaperone FACT (

Indexed as

Binding SitesDimerizationDNADNA-Binding ProteinsHigh Mobility Group ProteinsHistone ChaperonesHMGB ProteinsHumansModels, TheoreticalNucleic Acid ConformationNucleosomesProtein BindingSaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsDNADNA-Binding ProteinsFACT protein, S cerevisiaeHigh Mobility Group ProteinsHistone ChaperonesHMGB ProteinsNucleosomesSaccharomyces cerevisiae ProteinsSSRP1 protein, humanTranscriptional Elongation Factorschromatin dynamicschromatin regulationchromatin structureDNA-binding proteinFACThistone chaperoneHMGB domainnucleosomenucleosome reorganization

Identifiers

PMID29514976
PMCPMC5912460
OpenAlexW2789418401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.