Evidence map›Paper›PMID 29514908›Full record

ArticleJournal of virology2018

Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation.

Tongtong Wang, Qian Du, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tongtong Wang *College of Veterinary Medicine, Northwest A&F University, Yangling, China.
Qian Du *College of Veterinary Medicine, Northwest A&F University, Yangling, China.
Xingchen WuCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Yingying NiuCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Lijuan GuanCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Zhenyu WangCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Xiaomin ZhaoCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Shan-Lu LiuCenter for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.
Dewen TongCollege of Veterinary Medicine, Northwest A&F University, Yangling, China dwtong@nwafu.edu.cn yonghuang@nwafu.edu.cn.
Yong HuangCollege of Veterinary Medicine, Northwest A&F University, Yangling, China dwtong@nwafu.edu.cn yonghuang@nwafu.edu.cn.
Northwest A&F University · CNThe Ohio State University · US

Funding

IFITM-mediated Inhibition of HIV Infection and Viral CountermeasuresR01AI112381 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIU, SHAN-LU · 2014 to 2018
$1.7M
Inhibition of Ebolavirus Entry by IFITM2 ProteinR21AI109464 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIU, SHAN-LU · 2014 to 2015
$400k
NIAID NIH HHS R01 AI112381NIAID NIH HHS R21 AI109464
6 · The paper itself

Abstract

Porcine circovirus type 2 (PCV2) capsid protein (Cap) is a unique structure protein that plays pivotal roles in the process of viral replication and pathogenesis. Herein, we characterized a putative porcine Makorin RING finger protein 1 (pMKRN1) variant, an N-terminal-truncated variant of putative full-size porcine MKRN1 which has a unique expression pattern resulting from the porcine

Indexed as

AnimalsCapsid ProteinsCell LineCircoviridae InfectionsCircovirusHEK293 CellsHumansNerve Tissue ProteinsRibonucleoproteinsSwineSwine DiseasesUbiquitinationUbiquitin-Protein LigasesVirus ReplicationCapsid ProteinsMakorin ring finger protein 1Nerve Tissue ProteinsRibonucleoproteinsUbiquitin-Protein LigasesPCV2pMKRN1replicationubiquitination

Identifiers

PMID29514908
PMCPMC5952126
OpenAlexW2789546488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.