Evidence map›Paper›PMID 29514906›Full record

ArticleJournal of virology2018

A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus.

Yanmin Wan, Guobin Kang, Chithra Sreenivasan, Lance Daharsh, Junfeng Zhang, Wenjin Fan, Dan Wang, Hideaki Moriyama, Feng Li, Qingsheng Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Influenza D virus.Current opinion in virology · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yanmin WanNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Guobin KangNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Chithra SreenivasanDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Lance DaharshNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Junfeng ZhangNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Wenjin FanNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Dan WangDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.ORCID https://orcid.org/0000-0002-7263-8420
Hideaki MoriyamaSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Feng LiDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Qingsheng LiNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA qli@unl.edu.ORCID https://orcid.org/0000-0003-4101-4073
University of Nebraska–Lincoln · USSouth Dakota State University · US

Funding

Surveillance of Agricultural Injuries in the Central States RegionsU54OH010162 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RAUTIAINEN, RISTO HEIKKI · 2011 to 2025
$23.6M
Study of Novel Influenza C VirusR21AI107379 · NIAID · SOUTH DAKOTA STATE UNIVERSITY · PI LI, FENG · 2014 to 2015
$394k
NIAID NIH HHS R21 AI107379NIOSH CDC HHS U54 OH010162
6 · The paper itself

Abstract

Two lineages of influenza D virus (IDV) have been found to infect cattle and promote bovine respiratory disease complex, one of the most commonly diagnosed causes of morbidity and mortality within the cattle industry. Furthermore, IDV can infect other economically important domestic livestock, including pigs, and has the potential to infect humans, which necessitates the need for an efficacious vaccine. In this study, we designed a DNA vaccine expressing consensus hemagglutinin-esterase fusion (HEF) protein (FluD-Vax) and tested its protective efficacy against two lineages of IDV (D/OK and D/660) in guinea pigs. Animals that received FluD-Vax (

Indexed as

Hemagglutinins, ViralInfluenza VaccinesOrthomyxoviridae InfectionsThogotovirusVaccines, DNAViral Fusion ProteinsAnimalsApoptosisConsensus SequenceFemaleGuinea PigsProof of Concept Studyhemagglutinin esteraseHemagglutinins, ViralInfluenza VaccinesVaccines, DNAViral Fusion Proteinsconsensus sequenceDNA vaccineguinea pigshemagglutinin-esterase-fusion proteininfluenza D virus

Identifiers

PMID29514906
PMCPMC5952138
OpenAlexW2791126823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.