Evidence map›Paper›PMID 29514900›Full record

ArticleJournal of virology2018

Human T Lymphocytes Are Permissive for Dengue Virus Replication.

Guilherme F Silveira, Pryscilla F Wowk, Allan H D Cataneo, Paula F Dos Santos, Murilo Delgobo, Marco A Stimamiglio, Maria Lo Sarzi, Ana Paula F S Thomazelli, Ivete Conchon-Costa, Wander R Pavanelli and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
  2. T Cell Responses During Dengue Infection.Current topics in microbiology and immunology · 2026
    Review
  3. Article
  4. Dengue Dilemma: Navigating Cross-Reactivity and Immune Challenges.Current topics in microbiology and immunology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Frontiers in microbiology · 2021
    Article
  15. Article
  16. Dengue Infection Complicated by Hemophagocytic Lymphohistiocytosis: Experiences From 180 Patients With Severe Dengue.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  17. Article
  18. Article
  19. Frontiers in cellular and infection microbiology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Guilherme F SilveiraLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil.
Pryscilla F WowkLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil.
Allan H D CataneoLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil.
Paula F Dos SantosLaboratório de Imunobiologia, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Murilo DelgoboLaboratório de Imunobiologia, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Marco A StimamiglioLaboratório de Células Tronco, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil.
Maria Lo SarziSaúde da Família, Secretaria Municipal de Saúde de Cambé, Cambé, Paraná, Brazil.
Ana Paula F S ThomazelliLaboratório de Protozoologia Experimental, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
Ivete Conchon-CostaLaboratório de Protozoologia Experimental, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
Wander R PavanelliLaboratório de Protozoologia Experimental, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
Lis R V AntonelliLaboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
André BáficaLaboratório de Imunobiologia, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Daniel S MansurLaboratório de Imunobiologia, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Claudia N Duarte Dos SantosLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil clsantos@fiocruz.br juliano.bordignon@fiocruz.br.
Juliano BordignonLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil clsantos@fiocruz.br juliano.bordignon@fiocruz.br.ORCID https://orcid.org/0000-0002-1965-6152
Fundação Carlos Chagas · BRUniversidade Federal de Santa Catarina · BRUniversidade Estadual de Londrina · BRFundação Oswaldo Cruz · BRSecretaria Municipal de Saúde · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DV) infection can cause either a self-limiting flu-like disease or a threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, and B cells, can be infected by DV. However, despite the role of T lymphocytes in the control of DV replication, there remains a paucity of information on possible DV-T cell interactions during the disease course. In the present study, we have demonstrated that primary human naive CD4

Indexed as

AdolescentAdultApoptosisCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedDengueDengue VirusFemaleGranzymesHumansLymphocyte ActivationMaleMiddle AgedVirus ReplicationYoung AdultGranzymesdengue virusreplicationT lymphocytes

Identifiers

PMID29514900
PMCPMC5923084
OpenAlexW2789974574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.