Evidence map›Paper›PMID 29514862›Full record

ArticleEMBO reports2018

PAWS1 controls Wnt signalling through association with casein kinase 1α.

Polyxeni Bozatzi, Kevin S Dingwell, Kevin Zl Wu, Fay Cooper, Timothy D Cummins, Luke D Hutchinson, Janis Vogt, Nicola T Wood, Thomas J Macartney, Joby Varghese and 4 more

Open access · hybridAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  5. Article
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  7. Article
  8. Cells · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Casein Kinase 1α as a Regulator of Wnt-Driven Cancer.International journal of molecular sciences · 2020
    Review
  16. Article
  17. Article
  18. AGenes · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Polyxeni BozatziMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Kevin S DingwellThe Francis Crick Institute, London, UK.
Kevin Zl WuMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Fay CooperThe Francis Crick Institute, London, UK.
Timothy D CumminsMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Luke D HutchinsonMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Janis VogtMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Nicola T WoodMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Thomas J MacartneyMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Joby VargheseMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
Robert GourlayMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
David G CampbellMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK.
James C SmithThe Francis Crick Institute, London, UK jim.smith@crick.ac.uk g.sapkota@dundee.ac.uk.ORCID 0000-0003-2413-9392
Gopal P SapkotaMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK jim.smith@crick.ac.uk g.sapkota@dundee.ac.uk.ORCID 0000-0001-9931-3338
MRC Protein Phosphorylation and Ubiquitylation Unit · GBThe Francis Crick Institute · GB

Funding

Cancer Research UK FC001157Medical Research Council MC_U117597140Medical Research Council MC_U127092717Medical Research Council MC_UU_00018/6Medical Research Council MC_UU_12016/3Wellcome Trust FC001157
6 · The paper itself

Abstract

The BMP and Wnt signalling pathways determine axis specification during embryonic development. Our previous work has shown that PAWS1 (also known as FAM83G) interacts with SMAD1 and modulates BMP signalling. Here, surprisingly, we show that overexpression of PAWS1 in

Indexed as

Wnt Signaling PathwayAnimalsAxin Proteinbeta CateninBone Morphogenetic ProteinsCasein Kinase IalphaCell Line, TumorCell NucleusEctopic Gene ExpressionGene ExpressionGene Knockout TechniquesHumansIntracellular Signaling Peptides and ProteinsMultiprotein ComplexesPhosphorylationProtein BindingAXIN1 protein, humanAxin Proteinbeta CateninBone Morphogenetic ProteinsCasein Kinase IalphaFAM83G protein, humanIntracellular Signaling Peptides and ProteinsMultiprotein ComplexesXenopus ProteinsBMPCK1FAM83GPAWS1Wnt

Identifiers

PMID29514862
PMCPMC5891436
OpenAlexW2793775366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.