Evidence map›Paper›PMID 29514855›Full record

ArticleMolecular pharmacology2018

The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase II

Ragu Kanagasabai, Soumendrakrishna Karmahapatra, Corey A Kientz, Yang Yu, Victor A Hernandez, Evan E Kania, Jack C Yalowich, Terry S Elton

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Circumvention of Topoisomerase IIMolecular pharmacology · 2024
    Article
  2. Use of CRISPR/Cas9 with Homology-Directed Repair to Gene-Edit Topoisomerase IIThe Journal of pharmacology and experimental therapeutics · 2024
    Article
  3. Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ragu KanagasabaiDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.
Soumendrakrishna KarmahapatraDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.
Corey A KientzDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.
Yang YuDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.
Victor A HernandezDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.
Evan E KaniaDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.
Jack C YalowichDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio yalowich.1@osu.edu elton.8@osu.edu.
Terry S EltonDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio yalowich.1@osu.edu elton.8@osu.edu.
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Novel Topoisomerase II alpha isoform as a drug resistance determinantR01CA226906 · NCI · OHIO STATE UNIVERSITY · PI ELTON, TERRY S, YALOWICH, JACK C. · 2019 to 2023
$1.8M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA226906
6 · The paper itself

Abstract

DNA topoisomerase II

Indexed as

Drug Resistance, NeoplasmAntineoplastic Agents, AlkylatingCell LineCell NucleusDimerizationDNA Breaks, Double-StrandedDNA Topoisomerases, Type IIEtoposideHumansIsoenzymesK562 CellsLeukemia, Myeloid, AcuteRNA Processing, Post-TranscriptionalAntineoplastic Agents, AlkylatingDNA Topoisomerases, Type IIEtoposideIsoenzymes

Identifiers

PMID29514855
PMCPMC11033944
OpenAlexW2789457828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.