ArticleCirculation research2018
Cardiac Kir2.1 and Na
Open access · bronzeAbstract read
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Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events.Cardiovascular research · 2021Pooled it
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- A new approach methodology for studying intrinsic ventricular arrhythmias in Fabry disease.Frontiers in cardiovascular medicine · 2026Article
- Advanced cardiac organoid model for studying doxorubicin-induced cardiotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Calcium Homeostatic Feedback Control Predicts Atrial Fibrillation Initiation, Remodeling, and Progression.JACC. Clinical electrophysiology · 2025Article
- Paradoxical SERCA2a Dysregulation Contributes to Atrial Fibrillation in a Model of Diet-Induced Obesity.International journal of molecular sciences · 2025Article
- Propionic Acidemia-Induced Proarrhythmic Electrophysiological Alterations in Human iPSC-Derived Cardiomyocytes.Journal of inherited metabolic disease · 2025Article
- Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome.Cell discovery · 2025Review
- Alleviating the Effects of Short QT Syndrome Type 3 by Allele-Specific Suppression of theInternational journal of molecular sciences · 2024Article
- Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome.medRxiv : the preprint server for health sciences · 2024Article
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- The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3.Cardiovascular research · 2024Article
- Extracellular Kir2.1Circulation research · 2024Article
- High-throughput methods for cardiac cellular electrophysiology studies: the road to personalized medicine.American journal of physiology. Heart and circulatory physiology · 2024Review
- Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes.APL bioengineering · 2024Article
- In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition.Scientific reports · 2024Article
- Article
- Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byKir2.1 & Na2018
Authors and funding
19 authors at 4 institutions in 3 countries.
Daniela Ponce-BalbuenaFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Guadalupe Guerrero-SernaFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Carmen R ValdiviaFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Ricardo CaballeroDepartment of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain (R.C., M.P.-H., M.M., E.D.).
F Javier Diez-GuerraDepartamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Universidad Autónoma de Madrid, Spain (F.J.D.-G.).
Eric N Jiménez-VázquezFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Rafael J RamírezFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
André Monteiro da RochaFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Todd J HerronFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Katherine F CampbellFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
B Cicero WillisFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Francisco J AlvaradoDepartment of Molecular and Integrative Physiology (F.J.A., H.H.V.).
Manuel ZarzosoFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Kuljeet KaurFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Marta Pérez-HernándezDepartment of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain (R.C., M.P.-H., M.M., E.D.).
Marcos MatamorosDepartment of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain (R.C., M.P.-H., M.M., E.D.).
Héctor H ValdiviaFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.).
Eva DelpónDepartment of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain (R.C., M.P.-H., M.M., E.D.).
José JalifeFrom the Department of Internal Medicine and Center for Arrhythmia Research (D.P.-B., G.G.-S., C.R.V., E.N.J.-V., R.J.R., A.M.d.R., T.J.H., K.F.C., B.C.W., M.Z., K.K., H.H.V., J.J.) jjalife@umich.edu.
Hospital General Universitario Gregorio Marañón · ESLaboratoire d’immunologie intégrative du cancer · FRUniversidad Complutense de Madrid · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ES
Funding
THREE DIMENSIONAL VORTEX LIKE REENTRY IN CORONARY PERFUSED VENTRICULAR WALLP01HL039707 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI JALIFE, JOSE S · 1990 to 2010
$19.0MP3: Biophysical Mechanisms in two Arhythmogenic DiseasesP01HL087226 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI JALIFE, JOSE S · 2007 to 2012
$10.3MRyanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0MIntermolecular Interactions of NaV1.5 and Kir2.1 In Ion Channel DiseasesR01HL122352 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2015 to 2018
$1.9MNatural Agonists of Ryanodine Receptors: Structure-function Relationship and Antiarrhythmic PropertiesR01HL134344 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2017 to 2020
$1.9MCytosolic Calcium Sweeper in Cardiac MyocytesR01HL120108 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2014 to 2017
$1.5MNHLBI NIH HHS P01 HL039707NHLBI NIH HHS P01 HL087226NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL120108NHLBI NIH HHS R01 HL122352NHLBI NIH HHS R01 HL134344
Abstract
rationaleIn cardiomyocytes, Na
objectiveThe objective of this study was to test whether Na METHODS AND
resultsIn patch-clamp experiments, coexpression of trafficking-deficient mutants Kir2.1
conclusionsThe Na
Indexed as
Action PotentialsAdaptor Protein Complex 1AnimalsColoring AgentsHumansInduced Pluripotent Stem CellsKcnj10 ChannelMaleMembrane PotentialsMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedProtein TransportRatsAdaptor Protein Complex 1Coloring AgentsKcnj10 ChannelNAV1.5 Voltage-Gated Sodium ChannelPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedVoltage-Gated Sodium Channelsaction potentialsarrhythmias, cardiacelectrophysiologyGolgi apparatusion channels
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.