ArticleJournal of the American Heart Association2018
Left Ventricular Unloading Using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis.Journal of cardiovascular translational research · 2021Pooled it
- Long-term 5-year outcome of the randomized IMPRESS in severe shock trial: percutaneous mechanical circulatory support vs. intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction.European heart journal. Acute cardiovascular care · 2021Trial
- Procedural circulatory support-enabled intracoronary cell delivery in advanced dilated cardiomyopathy.iScience · 2026Article
- Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.Journal of cardiovascular translational research · 2026Article
- Case Report: Extracorporeal membrane oxygenation in acute coronary syndrome: a rare case of massive left ventricular thrombus.Frontiers in cardiovascular medicine · 2026Article
- Bailout percutaneous coronary intervention for iatrogenic left main coronary artery dissection under Impella CP support: a case report.European heart journal. Case reports · 2026Article
- Trends and outcomes of different mechanical circulatory support modalities for refractory cardiogenic shock in Takotsubo cardiomyopathy.American heart journal plus : cardiology research and practice · 2025Article
- Mechanical circulatory support reduces renal sympathetic nerve activity in an ovine model of acute myocardial infarction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Comparison of mechanical resuscitation by an LV Impella device to extracorporeal resuscitation using VAECMO in a large animal model.Scientific reports · 2025Article
- Intra-aortic Entrainment Pump for LV unloading: What Phase of the Cardiac Cycle Does the Device Unload?Journal of cardiac failure · 2025Article
- Temporary Mechanical Circulatory Support for Acute Myocardial Infarction Cardiogenic Shock.Methodist DeBakey cardiovascular journal · 2025Review
- Animal Models for Mechanical Circulatory Support: A Research Review.Reviews in cardiovascular medicine · 2024Review
- Restoration of Epicardial Blood Flow After Left Ventricular Unloading With the Impella CP Heart Pump in a Patient With STEMI Treated With Surgical Revascularization.Texas Heart Institute journal · 2024Article
- Treatment and Care of Patients with ST-Segment Elevation Myocardial Infarction-What Challenges Remain after Three Decades of Primary Percutaneous Coronary Intervention?Journal of clinical medicine · 2024Review
- Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support.The Journal of physiology · 2024Article
- Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading.Journal of cardiovascular translational research · 2024Article
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- DCM Support: cell therapy and circulatory support for dilated cardiomyopathy patients with severe ventricular impairment.ESC heart failure · 2023Article
- IABP versus Impella Support in Cardiogenic Shock: "In Silico" Study.Journal of cardiovascular development and disease · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDelivering therapeutic materials, like stem cells or gene vectors, to the myocardium is difficult in the setting of ischemic heart failure because of decreased coronary flow and impaired microvascular perfusion (MP). The aim of this study was to determine if mechanical left ventricular (LV) unloading with the Impella increases coronary flow and MP in a subacute myocardial infarction. METHODS AND
resultsAnterior transmural myocardial infarction (infarct size, 26.0±3.4%) was induced in Yorkshire pigs. At 2 weeks after myocardial infarction, 6 animals underwent mechanical LV unloading by Impella, whereas 4 animals underwent pharmacological LV unloading using sodium nitroprusside for 2 hours. LV unloading with Impella significantly reduced end-diastolic volume (-16±11mL,
conclusionsLV unloading using an Impella decreased EDWS and increased infarct MP without hemodynamic decompensation. Mechanical LV unloading is a novel and efficient approach to increase infarct MP in patients with subacute myocardial infarction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.