ArticleWorld journal of surgical oncology2018
Low heart rate variability relates to the progression of gastric cancer.
Article in World journal of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Heart rate variability suppression in cancer patients versus non-cancer controls: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Effects of the CALM intervention on cancer-related fatigue and heart rate variability in NSCLC: a randomized trial.Future oncology (London, England) · 2024Trial
- Study on the Diagnosis of Gastric Cancer by Magnetic Beads Extraction and Mass Spectrometry.BioMed research international · 2020Trial
- Effects of Traditional Chinese Medicine "Fuzheng Qingdu Decoction" on Autonomic Function and Cancer-Related Symptoms in Patients with Advanced Gastric Cancer undergoing Chemotherapy: A Controlled Trial.Integrative cancer therapiesTrial
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Cardiac autonomic dysfunction in patients with cancer: exploring the role of physical exercise.Journal of cancer research and clinical oncology · 2025Review
- Prediction of perioperative complications in colorectal cancerWorld journal of gastrointestinal surgery · 2025Article
- Connection between heart rate variability alterations and cancer in tumor patients.World journal of cardiology · 2025Article
- Predicting lymphovascular space invasion in early-stage cervical squamous cell carcinoma using heart rate variability.Frontiers in oncology · 2025Article
- Pulse rate variability is not the same as heart rate variability: findings from a large, diverse clinical population study.Frontiers in physiology · 2025Article
- Using heart rate variability to evaluate the association between the autonomic nervous system and coagulation function in patients with endometrial cancer.Oncology letters · 2024Article
- Tracking Cancer: Exploring Heart Rate Variability Patterns by Cancer Location and Progression.Cancers · 2024Article
- Prediction models for lymph node metastasis in cervical cancer based on preoperative heart rate variability.Frontiers in neuroscience · 2024Article
- Evidence of sex differences in cancer-related cardiac complications in mouse models of pancreatic and liver cancer.Physiological reports · 2023Article
- Association of heartbeat complexity with survival in advanced non-small cell lung cancer patients.Frontiers in neuroscience · 2023Article
- Prognostic implications of ultra-short heart rate variability indices in hospitalized patients with infective endocarditis.PloS one · 2023Article
- Prognostic role of short-term heart rate variability and deceleration/acceleration capacities of heart rate in extensive-stage small cell lung cancer.Frontiers in physiology · 2023Article
- Subclinical cardiac damage in cancer patients before chemotherapy.Heart failure reviews · 2022Review
- Autonomic nervous system activity under rotational shift programs: effects of shift period and gender.Industrial health · 2022Article
- Influence of Nicotine from Diverse Delivery Tools on the Autonomic Nervous and Hormonal Systems.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGastric cancer (GC) is one of the most common malignant gastrointestinal tumors with the high morbidity and mortality, affecting the quality of human life. This study aimed to identify the role of heart rate variability (HRV) in patients with GC.
methodsFrom January 2010 to June 2014, 383 consecutive patients diagnosed with GC were enrolled in this study. Clinical and pathological information from each patient were retrospectively recorded. HRV, including standard deviation of normal-to-normal RR intervals (SDNN) and root mean square of successive differences (RMSSD), were measured by electrocardiography.
resultsThe results showed that the SDNN and RMSSD in GC patients were 19.02 ± 13.58 ms and 21.64 ± 17.57 ms, respectively. HRV decreased with advanced clinical stage (P < 0.0001). HRV correlated with tumor size, tumor infiltration, lymph node metastasis and distant metastasis (P < 0.001); however, no correlation with tumor site and metastasis severity was found (P > 0.05). C-reactive protein (CRP) was higher in the low HRV group than that in high HRV group (P = 0.008).
conclusionsGC patients showed a lower HRV that was correlated with tumor stage. HRV decreased with tumor progression, which may be related to a mechanism involving vagal nerve excitement inhibiting the inflammatory reaction.
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