Evidence map›Paper›PMID 29514690›Full record

ArticleTrials2018

Effect of physical exercise on spontaneous physical activity energy expenditure and energy intake in overweight adults (the EFECT study): a study protocol for a randomized controlled trial.

Vitor Barreto Paravidino, Mauro Felippe Felix Mediano, Inácio Crochemore M Silva, Andrea Wendt, Fabrício Boscolo Del Vecchio, Fabiana Alves Neves, Bruno de Souza Terra, Erika Alvarenga Corrêa Gomes, Anibal Sanchez Moura, Rosely Sichieri

Abstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vitor Barreto ParavidinoDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil. vparavidino@gmail.com.
Mauro Felippe Felix MedianoEvandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
Inácio Crochemore M SilvaPost-graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Andrea WendtPost-graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Fabrício Boscolo Del VecchioPost-Graduate Program in Physical Education, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Fabiana Alves NevesDepartment of Physiology Science, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Bruno de Souza TerraResearch Laboratory of Exercise Sciences, Physical Education Center Admiral Adalberto Nunes, Brazilian Navy, Rio de Janeiro, Rio de Janeiro, Brazil.
Erika Alvarenga Corrêa GomesLaboratory of Exercise Sciences, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Anibal Sanchez MouraDepartment of Physiology Science, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rosely SichieriDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical exercise interventions have been extensively advocated for the treatment of obesity; however, clinical trials evaluating the effectiveness of exercise interventions on weight control show controversial results. Compensatory mechanisms through a decrease in energy expenditure and/or an increase in caloric consumption is a possible explanation. Several physiological mechanisms involved in the energy balance could explain compensatory mechanisms, but the influences of physical exercise on these adjustments are still unclear. Therefore, the present trial aims to evaluate the effects of exercise on non-exercise physical activity energy expenditure, energy intake and appetite sensations among active overweight/obese adults, as well as, to investigate hormonal changes associated with physical exercise.

methodsThis study is a randomized controlled trial with parallel, three-group experimental arms. Eighty-one overweight/obese adults will be randomly allocated (1:1:1 ratio) to a vigorous exercise group, moderate exercise group or control group. The trial will be conducted at a military institution and the intervention groups will be submitted to exercise sessions in the evening, three times a week for 65 min, during a 2-week period. The primary outcome will be total spontaneous physical activity energy expenditure during a 2-week period. Secondary outcomes will be caloric intake, appetite sensations and laboratorial biomarkers. Intention-to-treat analysis will be performed using linear mixed-effects models to evaluate the effect of treatment-by-time interaction on primary and secondary outcomes. Data analysis will be performed using SAS 9.3 and statistical significance will be set at p < 0.05. DISCUSSION: The results of the present study will help to understand the effect of physical exercise training on subsequent non-exercise physical activity, appetite and energy intake as well as understand the physiological mechanisms underlying a possible compensatory phenomenon, supporting the development of more effective interventions for prevention and treatment of obesity.

trial registrationPhysical Exercise and Energy Balance trial registry, trial registration number: NCT 03138187 . Registered on 30 April 2017.

Indexed as

EatingEnergy IntakeEnergy MetabolismExerciseAdaptation, PhysiologicalAdolescentAppetite RegulationBrazilExercise TherapyHumansMaleObesityRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeYoung AdultCompensatory effectEnergy intakeExercise trainingObesityPhysical activity energy expenditure

Identifiers

PMID29514690
PMCPMC5842658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.