SynthesisBMC oral health2018
Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis.
Synthesis in BMC oral health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Association of Single Nucleotide Polymorphisms in the Cyclooxygenase-2 (COX-2) Gene with Periodontal Disease-A Systematic Review with Meta-Analysis and Implications for Personalized Dentistry.Journal of personalized medicine · 2025Review
- Identification of Oxidative Stress-Related Shared Biomarkers in Vitiligo and Periodontitis: A Bioinformatics and Machine Learning Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Novel Mouth Rinse Displaying Analgesic and Anti-inflammatory Properties: AnAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2025Article
- Epoxidase inhibitor-aspirin resistance and the relationship with genetic polymorphisms: a review.The Journal of international medical research · 2024Review
- Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens.BMC oral health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore the relationship of COX2 -765G/C polymorphism on periodontitis risk among Chinese population.
methodsThe databases of PubMed, Springer Link, Ovid, Chinese Wanfang Databases, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine were searched up to January 2017. The overall result and subgroup analysis results were combined using fixed-effect or random-effect based on the heterogeneity.
resultsFinally, 7 case-control publications including 1399 periodontitis cases and 1663 controls were identified according to the inclusion criteria. In the total analyses, COX2 -765G/C polymorphism had nonsignificant association on periodontitis risk in all models. The subgroup analyses suggested a significantly increased risk of periodontitis in studies with population-based controls and a significantly decreased risk in studies with hospital-based controls.
conclusionsThis meta-analysis indicated that COX2 -765G/C polymorphism had significantly affect on periodontitis risk among Chinese individuals, which should be confirmed by other ethnic groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.