Evidence map›Paper›PMID 29514525›Full record

ArticleJournal of immunotoxicology2018

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague-Dawley rats and B

Rachel P Frawley, Matthew Smith, Mark F Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E Kissling, Shawn Harris, Dori Germolec

Open access · goldAbstract read
In one paragraph

Article in Journal of immunotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS).Environmental health : a global access science source · 2023
    Review
  14. Article
  15. Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants.International journal of environmental research and public health · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. News Feature: How "forever chemicals" might impair the immune system.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rachel P Frawleya Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.ORCID 0000-0001-8490-8240
Matthew Smithb Richard Bland College of William & Mary , South Prince George , VA , USA.
Mark F Cestaa Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.
Schantel Hayes-Bouknightc Charles River Laboratories, Inc. , Durham , NC , USA.
Chad Blystonea Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.
Grace E Kisslinga Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.
Shawn Harrisd Social & Scientific Systems, Inc. , Durham , NC , USA.
Dori Germoleca Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.
National Institute of Environmental Health Sciences · USCharles River Laboratories (United States) · USRichard Bland College · USSocial and Scientific Systems (United States) · US

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
Chemsitry Support Services to ETP for NanotechnologyN01ES55551 · NIEHS · BATTELLE MEMORIAL INSTITUTE · PI GRAVES, STEVE · 2007 to 2016
$12.8M
POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITYN01ES55538 · NIEHS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SMITH, MATTHEW · 2007 to 2012
$5.7M
Intramural NIH HHS Z99 ES999999NIEHS NIH HHS N01 ES055538NIEHS NIH HHS N01 ES055551NIEHS NIH HHS N01ES55538NIEHS NIH HHS N01ES55551
6 · The paper itself

Abstract

Poly- and perfluoroalkyl substances (PFAS) are chemically and thermally stable, hydrophobic, lipophobic compounds used in stain repellants and water and oil surfactants, and associated with immunosuppression and peroxisome proliferator activity. Perfluoro-n-decanoic acid (PFDA, (CF

Indexed as

Administration, OralAnimalsCells, CulturedDecanoic AcidsFemaleFluorocarbonsHepatocytesHumansImmunosuppression TherapyLiverMiceMice, Inbred C3HMice, Inbred C57BLNecrosisOrthomyxoviridaeOrthomyxoviridae InfectionsDecanoic AcidsFluorocarbonsperfluorodecanoic acidSurface-Active AgentshepatotoxicityPerfluoro-n-decanoic acid (PFDA)poly-/perfluoroalkyl substance (PFAS)

Identifiers

PMID29514525
PMCPMC12406128
OpenAlexW2790582361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.