ArticleAsian-Australasian journal of animal sciences2018
Genome wide association study of fatty acid composition in Duroc swine.
Article in Asian-Australasian journal of animal sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Gut Microbiota-Derived Metabolites to Regulate Intramuscular Fat Deposition in Pigs.Microorganisms · 2026Review
- Evaluation of genetic effects on the fatty acid composition of intramuscular fat and backfat of the endangered Angler Saddleback pig.Archives animal breeding · 2026Article
- Identification of genomic regions associated with fatty acid metabolism across blood, liver, backfat and muscle in pigs.Genetics, selection, evolution : GSE · 2024Article
- Genome-Wide Association Study and Identification of Candidate Genes for Intramuscular Fat Fatty Acid Composition in Ningxiang Pigs.Animals : an open access journal from MDPI · 2023Article
- Young SINEs in pig genomes impact gene regulation, genetic diversity, and complex traits.Communications biology · 2023Article
- Lipo-nutritional quality of pork: The lipid composition, regulation, and molecular mechanisms of fatty acid deposition.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Chemical Characteristics of Croatian TraditionalMolecules (Basel, Switzerland) · 2021Article
- Enhancing the Nutritional Value of Red Meat through Genetic and Feeding Strategies.Foods (Basel, Switzerland) · 2021Review
- Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig.Scientific reports · 2020Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGenome wide association study was conducted to identify and validate candidate genes associated with fatty acid composition of pork.
methodsA total of 480 purebreed Duroc pigs were genotyped using IlluminaPorcine60k bead chips while the association test was implemented following genome-wide rapid association using Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approach.
resultsA total of 25, 29, and 16 single nucleotide polymorphisms (SNPs) were significantly associated with stearic (18:0), oleic (18:1) and saturated fatty acids (SFA), respectively. Genome wide significant variants were located on the same region of swine chromosome 14 (SSC14) that spanned from 120 to 124 Mb. Top SNP ALGA008191 was located at 5 kb near the stearoyl-CoA desaturase (SCD) gene. This gene is directly involved in desaturation of stearic acid into oleic acid. General relationship of significant SNPs showed high linkage disequilibrium thus genome-wide signals was attributed to SCD gene. However, understanding the role of other genes like elongation of very long chain fatty acids-3 (ELOVL3) located on this chromosomal segment might help in further understanding of metabolism and biosynthesis of fatty acids.
conclusionOverall, this study provides evidence that validates SCD gene as strong candidate gene associated with fatty acid composition in Duroc pigs. Moreover, this study confirms significant SNPs near ELOVL3 gene.
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