Evidence map›Paper›PMID 29514308›Full record

ArticleThe Journal of infectious diseases2018

Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing.

Carol A Gilchrist, James A Cotton, Cecelia Burkey, Tuhinur Arju, Allissia Gilmartin, Ye Lin, Emtiaz Ahmed, Kevin Steiner, Masud Alam, Shahnawaz Ahmed and 11 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02764918 (Field Studies of Cryptosporidiosis and Enteropathogens in Bangladesh), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02764918 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Field Studies of Cryptosporidiosis and Enteropathogens in Bangladesh

TypeobservationalSponsorUniversity of VirginiaRan2024 to 2029Enrolled150ConditionsCryptosporidiosis
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Large-scale molecular epidemiological survey ofJournal of clinical microbiology · 2026
    Article
  2. Molecular detection and zoonotic potential ofFood and waterborne parasitology · 2026
    Article
  3. Preparation of Cryptosporidium for Whole-Genome Sequencing.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Observational
  6. Deciphering a cryptic minefield: A guide toCurrent research in parasitology & vector-borne diseases · 2025
    Review
  7. Article
  8. Article
  9. Phylogenomic reconstruction ofbioRxiv : the preprint server for biology · 2024
    Article
  10. Current tropical medicine reports · 2024
    Review
  11. Article
  12. InvestigatingInternational journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. An update onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Review
  18. Article
  19. Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Observational
  20. Challenges forGenes · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Carol A GilchristDepartment of Medicine, University of Virginia, Charlottesville.
James A CottonWellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
Cecelia BurkeyDepartment of Medicine, University of Virginia, Charlottesville.
Tuhinur ArjuInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Allissia GilmartinDepartment of Medicine, University of Virginia, Charlottesville.
Ye LinDepartment of Statistics, University of Virginia, Charlottesville.
Emtiaz AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Kevin SteinerDepartment of Medicine, University of Virginia, Charlottesville.
Masud AlamInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Shahnawaz AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Guy RobinsonCryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital.
Sultan Uz ZamanInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Mamun KabirInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Mandy SandersWellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
Rachel M ChalmersCryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital.
Tahmeed AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Jennie Z MaDepartment of Public Health Sciences, University of Virginia, Charlottesville.
Rashidul HaqueInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Abu S G FaruqueInternational Centre for Diarrhoeal Disease Research, Bangladesh.
Matthew BerrimanWellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
William A PetriDepartment of Medicine, University of Virginia, Charlottesville.
International Centre for Diarrhoeal Disease Research · BDUniversity of Virginia · USWellcome Sanger Institute · GBSingleton Hospital · GB

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
NIAID NIH HHS R01 AI043596NIAID NIH HHS T32 AI055432Wellcome Trust 206194
6 · The paper itself

Abstract

We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over <300 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality, and varied clinical presentations of cryptosporidiosis in this population.

Indexed as

Genetic VariationBangladeshCryptosporidiosisCryptosporidiumFemaleFungal ProteinsGenotypeGenotyping TechniquesHumansInfantInfant, NewbornMalePoverty AreasProspective StudiesWhole Genome SequencingFungal Proteins

Identifiers

PMID29514308
PMCPMC6009673
OpenAlexW2793142290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.