Evidence map›Paper›PMID 29514254›Full record

Trial reportThe Journal of infectious diseases2018

Increased Risk of HIV Acquisition Among Women Throughout Pregnancy and During the Postpartum Period: A Prospective Per-Coital-Act Analysis Among Women With HIV-Infected Partners.

Kerry A Thomson, James Hughes, Jared M Baeten, Grace John-Stewart, Connie Celum, Craig R Cohen, Kenneth Ngure, James Kiarie, Nelly Mugo, Renee Heffron and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 9 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 9 syntheses or guidelines pooled it, 297 citations in OpenAlex.

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138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kerry A ThomsonDepartment of Epidemiology, University of Washington, Seattle.
James HughesDepartment of Biostatistics, University of Washington, Seattle.
Jared M BaetenDepartment of Epidemiology, University of Washington, Seattle.
Grace John-StewartDepartment of Epidemiology, University of Washington, Seattle.
Connie CelumDepartment of Epidemiology, University of Washington, Seattle.
Craig R CohenDepartments of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.
Kenneth NgureDepartment of Global Health, University of Washington, Seattle.
James KiarieDepartment of Global Health, University of Washington, Seattle.
Nelly MugoDepartment of Global Health, University of Washington, Seattle.
Renee HeffronDepartment of Epidemiology, University of Washington, Seattle.
Partners in Prevention HSV/HIV Transmission Study and Partners PrEP Study Teams
University of Washington · USJomo Kenyatta University of Agriculture and Technology · KEKenya Medical Research Institute · KEUniversity of California, San Francisco · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Institute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1M
NCATS NIH HHS TL1 TR000422NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

Background: Understanding the absolute and relative risk of human immunodeficiency virus type 1 (HIV) acquisition during pregnancy and the postpartum period can inform HIV prevention strategies for women. Methods: We used a complementary log-log model and data from 2751 HIV-serodiscordant couples to compare the probability of HIV acquisition among women per sex act during early pregnancy, late pregnancy, the postpartum period, and the nonpregnant period. Results: At total of 686 pregnancies were identified, and 82 incident HIV infections occurred. After adjustment for condom use, age, preexposure prophylaxis (PrEP) use, and HIV viral load, the per-act probability of HIV acquisition was higher in late pregnancy (adjusted relative risk [aRR], 2.82; P = .01) and the postpartum period (aRR, 3.97; P = .01) as compared to that during nonpregnant period. For a 25-year-old woman not taking PrEP, the HIV acquisition probability per condomless sex act with an HIV-infected male partner with a viral load of 10 000 copies/mL was 0.0011 (95% confidence interval [CI] 0.005-0.0019), 0.0022 (95% CI, 0.0004-0.0093), 0.0030 (95% CI, 0.0007-0.0108), and 0.0042 (95% CI, 0.0007-0.0177) during the nonpregnant period, early pregnancy, late pregnancy, and the postpartum period, respectively. Conclusion: The HIV acquisition probability per condomless sex act steadily increased during pregnancy and was highest during the postpartum period, suggesting that biological changes during pregnancy and the postpartum period increase HIV susceptibility among women.

Indexed as

CoitusDisease SusceptibilityDisease Transmission, InfectiousPostpartum PeriodPregnancySexual PartnersAdultFemaleHIV InfectionsHumansIncidenceMaleRisk Assessment

Identifiers

PMID29514254
PMCPMC5989601
OpenAlexW2793487607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.