ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
Priorities for Decreasing Morbidity and Mortality in Children With Advanced HIV Disease.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Determinants of HIV related mortality in African children on antiretroviral therapy: clinical and immunological insights from a systematic review and meta-analysis.AIDS research and therapy · 2025Pooled it
- Postdischarge interventions for children hospitalized with severe acute malnutrition: a systematic review and meta-analysis.The American journal of clinical nutrition · 2021Pooled it
- Impact of maternal HIV infection on pregnancy and labor complication and perinatal health outcomes: a South African retrospective study.Archives of gynecology and obstetrics · 2026Article
- Trends of severe HIV disease and mortality among children in rural Tanzania.HIV medicine · 2025Article
- High Incidence of Tuberculosis in Young Children Living With HIV in the Western Cape, South Africa.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Article
- Outcomes of ABO-incompatible liver transplantation in end-stage liver disease patients co-infected with hepatitis B and human immunodeficiency virus.World journal of gastroenterology · 2023Article
- Current situation of fungal diseases in Eritrea.Mycoses · 2022Article
- Attrition and associated factors among children living with HIV at a tertiary hospital in Eritrea: a retrospective cohort analysis.BMJ paediatrics open · 2022Article
- Levels of vaccination coverage among HIV-exposed children in China: a retrospective study.Infectious diseases of poverty · 2021Article
- Observational
- Children and their families are entitled to the benefits of differentiated ART delivery.Journal of the International AIDS Society · 2020Article
- Tuberculosis Treatment Outcomes Among Children in Rural Southern Mozambique: A 12-year Retrospective Study.The Pediatric infectious disease journal · 2019Article
- Filling the Gaps for Enhancing the Effectiveness of Community-Based Programs Combining Treatment and Prevention of Child Malnutrition: Results from the Rainbow Project 2015⁻17 in Zambia.International journal of environmental research and public health · 2018Article
- Managing Advanced HIV Disease in a Public Health Approach.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- The Persistent Challenge of Advanced HIV Disease and AIDS in the Era of Antiretroviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Advanced HIV Disease at Antiretroviral Therapy Initiation and Treatment Outcomes Among Children and Adolescents Compared to Adults Living With HIV in Kinshasa, Democratic Republic of the Congo.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Early mortality and morbidity remain high in children initiating antiretroviral therapy (ART), especially in sub-Saharan Africa. Many children still present with advanced human immunodeficiency virus (HIV) disease. Tuberculosis, pneumonia, and severe bacterial infections are the main causes of hospital admission in HIV-infected children. In contrast to adults with advanced HIV disease, cryptococcal disease is not common in childhood, although there is a peak in infancy and adolescence. Interventions such as TB screening in symptomatic children, and isoniazid and cotrimoxazole prophylaxis should be implemented. There is evidence suggesting that rapid initiation (within 1 week) of ART in children with severe malnutrition or those with advanced HIV disease admitted to hospital is not beneficial and should be delayed until their condition has been stabilized. Research informing the prevention of severe bacterial infections, the management of pediatric immune reconstitution inflammatory syndrome, and other potential strategies to decrease morbidity and mortality in HIV-infected children are urgently needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.