Evidence map›Paper›PMID 29514145›Full record

Observational studyMedical principles and practice : international journal of the Kuwait University, Health Science Centre2018

Preoperative Midregional Pro-Adrenomedullin and High-Sensitivity Troponin T Predict Perioperative Cardiovascular Events in Noncardiac Surgery.

Mlađjan Golubović, Radmilo Janković, Dušan Sokolović, Vladan Ćosić, Vera Maravić-Stojkovic, Tomislav Kostić, Zoran Perišić, Nebojša Lađević

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Myocardial injury before noncardiac surgery.Frontiers in cardiovascular medicine · 2023
    Review
  6. Review
  7. Potential New Approaches in Predicting Adverse Cardiac Events One Month after Major Vascular Surgery.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019
    Article
  8. Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mlađjan GolubovićCenter for Anesthesiology and Reanimatology, Clinical Center Nis, Niš, Serbia.
Radmilo JankovićCenter for Anesthesiology and Reanimatology, Clinical Center Nis, Niš, Serbia.
Dušan SokolovićFaculty of Medicine, University of Nis, Niš, Serbia.
Vladan ĆosićCenter for Biochemistry, Clinical Center Nis, Niš, Serbia.
Vera Maravić-StojkovicInstitute for Cardiovascular Diseases, Belgrade, Serbia.
Tomislav KostićFaculty of Medicine, University of Nis, Niš, Serbia.
Zoran PerišićFaculty of Medicine, University of Nis, Niš, Serbia.
Nebojša LađevićCenter for Anesthesiology and Reanimatology, Clinical Center of Serbia, Belgrade, Serbia.
University of Nis · RSInstitute for Cardiovascular Diseases of Vojvodina · RSUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe evaluated the utility of preoperative midregional (MR) pro-adrenomedullin (proADM) and cardiac troponin T (TnT) for improved detection of patients at high risk for perioperative cardiac events and mortality after major noncardiac surgery. SUBJECTS AND

methodsThis prospective, single-center, observational study enrolled 79 patients undergoing major noncardiac surgery. After initial clinical assessment (clinical history, physical examination, echocardiogram, blood tests, and chest X-ray), MR-proADM and high-sensitivity TnT (hsTnT) were measured within 48 h prior to surgery by immunoluminometric and electrochemiluminescence immunoassay. Patients were followed by the consulting physician until discharge or up to 14 days in the hospital after surgery. Perioperative cardiac events included myocardial infarction and development or aggravation of congestive heart failure. Data were compared between patients who developed target events and event-free patients.

resultsWithin 14 days of monitoring, 14 patients (17.72%) developed target events: 9 (11.39%) died and 5 (6.33%) developed cardiovascular events. The average age of the patients was 71.29 ± 6.62 years (range: 55-87). Sex, age, and hsTnT did not significantly differ between groups. MR- proADM concentration was higher in deceased patients (p = 0.01). The upper quartile of MR-proADM was associated with a fatal outcome (66.7 vs. 20.0%, p < 0.01) and with cardiovascular events (64.3 vs. 16.9%, p < 0.01). MR-proADM above the cutoff value (≥0.85) was associated with a fatal outcome (88.9 vs. 20.0%, p < 0.01) and cardiovascular events (71.4 vs. 28.6%, p < 0.01); this association was not observed for hsTnT.

conclusionPreoperative measurement of MR-proADM provides useful information for perioperative cardiac events in high-risk patients scheduled for noncardiac surgery.

Indexed as

AdrenomedullinAdultBiomarkersFemaleHeart FailureHumansMaleMiddle AgedPreoperative CareProspective StudiesRisk FactorsSurgical Procedures, OperativeTroponin TAdrenomedullinBiomarkersTroponin THigh-sensitivity troponinMidregional pro-adrenomedullinPeriooperative complications

Identifiers

PMID29514145
PMCPMC6062667
OpenAlexW2792448414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.