ArticleCell reports2018
Directional Reaching for Water as a Cortex-Dependent Behavioral Framework for Mice.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed.
- Article
- Toward video-LLM driven workflow for behavioral segmentation and scoring in mice performing a skilled water-reaching task: an evaluation of recent LLM models.Neurophotonics · 2026Article
- A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026Article
- Eye-head coordination during goal-directed orienting in mice.Communications biology · 2026Article
- Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement.PLoS biology · 2026Article
- Eye-head coordination during goal-directed orienting in mice.bioRxiv : the preprint server for biology · 2026Article
- Basal ganglia output dynamically controls skilled forelimb kinematics in real time.bioRxiv : the preprint server for biology · 2026Article
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
- Differential participation of the corticospinal and corticorubral neurons during motor execution in the rat.Scientific reports · 2025Article
- Purkinje Cell Spatial Correlation Dynamics Are Key to Cerebellar Cortical Contributions to Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- Separating cognitive and motor processes in the behaving mouse.Nature neuroscience · 2025Article
- Forestwalk: A Machine Learning Workflow Brings New Insights Into Posture and Balance in Rodent Beam Walking.The European journal of neuroscience · 2025Article
- Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task.Journal of neurophysiology · 2024Article
- An output-null signature of inertial load in motor cortex.Nature communications · 2024Article
- Exploration biases forelimb reaching strategies.Cell reports · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optogenetic tools and imaging methods for recording and manipulating brain activity have boosted the field of neuroscience in unprecedented ways. However, behavioral paradigms for mice lag behind those of primates, limiting the full potential of such tools. Here, we present an innovative behavioral framework in which head-fixed mice directionally reach for water droplets, similar to the primate "center-out" reaching task. Mice rapidly engaged in the task, performed hundreds of trials, and reached in multiple directions when droplets were presented at different locations. Surprisingly, mice used chemosensation to determine the presence of water droplets. Optogenetic inactivation of the motor cortex halted the initiation and rapidly diverted the trajectory of ongoing movements. Layer 2/3 two-photon imaging revealed robust direction selectivity in most reach-related neurons. Finally, mice performed directional reaching instructed by vibratotactile stimuli, demonstrating the potential of this framework for studying, in addition to motor control, sensory processing, and decision making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.