ArticleCell metabolism2018
Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.
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Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
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57 citing papers in PubMed, 99 citations in OpenAlex.
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Authors and funding
16 authors at 2 institutions in 1 country.
Kevin M TharpProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Michael S KangUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Greg A TimblinDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jon DempersmierProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Garret E DempseyProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Peter-James H ZushinProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jaime BenavidesProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Catherine ChoiProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Catherine X LiProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Amit K JhaDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Shingo KajimuraDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Kevin E HealyDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Hei Sook SulProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kaoru SaijoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Sanjay KumarDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Andreas StahlProgram for Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: astahl@berkeley.edu.
University of California, Berkeley · USUniversity of California, San Francisco · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MMolecular mechanisms of UCP1-independent pathways in metabolic healthR01DK097441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shingo Kajimura · 2012 to 2026
$5.9MImmunology & Pathogenesis Program Training GrantT32AI100829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gregory M Barton, ELLEN A ROBEY · 2012 to 2026
$4.7MBiophysical Control of Cell Form and Function by Single Actomyosin Stress Fibers: Instrument SupplementR01GM122375 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KUMAR, SANJAY · 2017 to 2025
$2.7MCellular mechanobiology and engineering of active brown adipose tissueR01DK118940 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI KUMAR, SANJAY, STAHL, ANDREAS · 2019 to 2022
$2.3MDEPENDENCE OF THERMOGENESIS AND BROWN ADIPOSE TISSUE FUNCTION ON FATP1 AND CD36R01DK089202 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI STAHL, ANDREAS · 2011 to 2015
$1.9MMatrix assisted cell transplantation of brown fatR01DK101293 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, STAHL, ANDREAS · 2014 to 2017
$1.7MA Zeiss LSM 710 confocal microscope for the Biological Imaging Facility at the US10RR026866 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUZIN, STEVEN EARL · 2010 to 2010
$419kHigh-throughput Analysis of MicroRNA Regulation of Stem Cell MechanobiologyR21EB025017 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI KUMAR, SANJAY · 2017 to 2018
$411kNCRR NIH HHS S10 RR026866NIAID NIH HHS T32 AI100829NIBIB NIH HHS R21 EB025017NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK089202NIDDK NIH HHS R01 DK097441NIDDK NIH HHS R01 DK101293NIDDK NIH HHS R01 DK118940NIGMS NIH HHS R01 GM122375
Abstract
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve metabolic homeostasis. Here, we demonstrate that BAT utilizes actomyosin machinery to generate tensional responses following adrenergic stimulation, similar to muscle tissues. The activation of actomyosin mechanics is critical for the acute induction of oxidative metabolism and uncoupled respiration in UCP1
Indexed as
ActomyosinAdaptor Proteins, Signal TransducingAdipocytes, BeigeAdipocytes, BrownAdipose Tissue, BeigeAdipose Tissue, BrownAnimalsCell Cycle ProteinsCell RespirationCells, CulturedDisease Models, AnimalHomeostasisMiceOxygenPhosphoproteinsSignal TransductionActomyosinAdaptor Proteins, Signal TransducingCell Cycle ProteinsOxygenPhosphoproteinsTrans-ActivatorsUcp1 protein, mouseUncoupling Protein 1Wwtr1 protein, mouseYap1 protein, mouseYAP-Signaling Proteinsactomyosinbeige adiposebrown adiposemechanobiologymetabolismoxidative metabolismthermogenesisUCP1uncoupled respirationYAP/TAZ
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