ReviewMemorias do Instituto Oswaldo Cruz2018
The war on cryptococcosis: A Review of the antifungal arsenal.
Review in Memorias do Instituto Oswaldo Cruz, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 77 citations in OpenAlex.
- Central Nervous System Fungal Infections in Pakistan: A Narrative Review and Descriptive Synthesis.Cureus · 2026Review
- Development of a Multiplex qPCR to Detect and IdentifyACS omega · 2025Article
- The flippases Apt1 and Apt2 differentially influence extracellular vesicle cargo and polysaccharide secretion in Cryptococcus neoformans.Journal of proteomics · 2025Article
- Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity.Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- Broad Antifungal Spectrum of the Pore-Forming Peptide C14R AgainstPathogens (Basel, Switzerland) · 2025Article
- Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation inFrontiers in cellular and infection microbiology · 2025Article
- Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity ofTissue barriers · 2025Review
- Integrative Proteome and Metabolomics Analyses of Cryptococcus neoformans Responses to Melanin Substrates Niger seed and L-DOPA.Current microbiology · 2024Article
- Funding for research on cryptococcal disease: an analysis based on the G-finder report.IMA fungus · 2024Article
- Cryptococcal endophthalmitis and meningitis in an immunocompetent middle-aged woman: A case report.IDCases · 2024Article
- A multi-arm, parallel, preclinical study investigating the potential benefits of acetazolamide, candesartan, and triciribine in combination with fluconazole for the treatment of cryptococcal meningoencephalitis.European journal of pharmacology · 2023Article
- A comprehensive review on potential applications of metallic nanoparticles as antifungal therapies to combat human fungal diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Connecting Cryptococcal Meningitis and Gut Microbiome.International journal of molecular sciences · 2023Review
- Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase.Microbiology spectrum · 2023Article
- Antibacterial activities of anthraquinones: structure-activity relationships and action mechanisms.RSC medicinal chemistry · 2023Review
- Cyclosporine Affects the Main Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2023Article
- Advances in the Phytochemical Characterisation and Bioactivities ofPlants (Basel, Switzerland) · 2023Article
- Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities ofAntibiotics (Basel, Switzerland) · 2023Article
- Unveiling the Chemical Composition and Biological Properties ofPlants (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cryptococcal meningitis is the most common central nervous system infection in the world today. It occurs primarily, but not exclusively, in immunocompromised individuals and despite substantial improvement in management of clinical events like AIDS, the numbers of cases of cryptococcosis remain very high. Unfortunately, despite several antifungal agents available for treatment, morbidity and mortality rates remain high with this fungal infection. In this Review, we will describe the treatments and strategies for success, identify the failures, and provide insights into the future developments / improvements for management. This sugar-coated yeast can play havoc within the human brain. Our goals must be to either prevent or diagnose disease early and treat aggressively with all our clinical tools when disease is detected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.