ArticlePloS one2018
Peripheral neuropathy in patients with multiple sclerosis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Morphological and functional assessment of the vagus nerve in multiple sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Peripheral nervous system in multiple sclerosis-understanding the involvement via autonomic nervous system.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Strain and sex differences in somatosensation and sociability during experimental autoimmune encephalomyelitis.Brain, behavior, & immunity - health · 2021Article
- Abnormal Dynamic Pupillometry Relates to Neurologic Disability and Retinal Axonal Loss in Patients With Multiple Sclerosis.Translational vision science & technology · 2021Article
- Progressive Loss of Corneal and Retinal Nerve Fibers in Patients With Multiple Sclerosis: A 2-Year Follow-up Study.Translational vision science & technology · 2020Article
- The diversity of neuronal phenotypes in rodent and human autonomic ganglia.Cell and tissue research · 2020Review
- Research on lower extremity health in patients with multiple sclerosis: a systematic scoping review.Journal of foot and ankle research · 2020Article
- Advances in the Understanding and Management of Chronic Pain in Multiple Sclerosis: a Comprehensive Review.Current pain and headache reports · 2019Review
- Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Relapsing paralytic ileus in multiple sclerosis requiring surgery: a video case report.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS.
methods73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT).
resultsPatients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023).
conclusionsPatients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.
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