ReviewAngewandte Chemie (International ed. in English)2018
The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
Review in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Generalized Analysis of Electrophilic Small Molecules.Angewandte Chemie (International ed. in English) · 2026Article
- NMR-Solver: automated structure elucidation via large-scale spectral matching and physics-guided fragment optimization.Nature communications · 2026Article
- Programmable Microwaveable Chemistry in the Chemputer.Angewandte Chemie (International ed. in English) · 2026Article
- Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology.Journal of the American Chemical Society · 2025Review
- Automated Iterative N─C and C─C Bond Formation.Angewandte Chemie (International ed. in English) · 2025Article
- A Cobotic, Digitally Controlled Schlenk-line Unlocks Access to Elusive Lewis-Base Stabilised Copper Bis(Disilylamides).Angewandte Chemie (International ed. in English) · 2025Article
- Universal peptide synthesis via solid-phase methods fused with chemputation.Nature communications · 2025Article
- Atom-by-Atom Iterative Synthetic Logic: Laying the Foundation for Programmable Automated Construction of Small Organic Molecules.ACS central science · 2025Review
- Five-membered heterocycles as promising platforms for molecular logic gate construction.RSC advances · 2025Review
- Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts.Nature communications · 2025Article
- Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day.Nature communications · 2024Article
- Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers.Nature communications · 2024Article
- An integrated self-optimizing programmable chemical synthesis and reaction engine.Nature communications · 2024Article
- Automation to Enable High-Throughput Chemical Proteomics.Journal of proteome research · 2023Review
- Open-Source Chromatographic Data Analysis for Reaction Optimization and Screening.ACS central science · 2023Article
- Photo-Induced Homologation of Carbonyl Compounds for Iterative Syntheses.Angewandte Chemie (International ed. in English) · 2022Article
- The way to AI-controlled synthesis: how far do we need to go?Chemical science · 2022Review
- Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century.Chemical reviews · 2022Review
- HPLC-Based Automated Synthesis of Glycans in Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Digitizing Chemical Synthesis in 3D Printed Reactionware.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Today we are poised for a transition from the highly customized crafting of specific molecular targets by hand to the increasingly general and automated assembly of different types of molecules with the push of a button. Creating machines that are capable of making many different types of small molecules on demand, akin to that which has been achieved on the macroscale with 3D printers, is challenging. Yet important progress is being made toward this objective with two complementary approaches: 1) Automation of customized synthesis routes to different targets by machines that enable the use of many reactions and starting materials, and 2) automation of generalized platforms that make many different targets using common coupling chemistry and building blocks. Continued progress in these directions has the potential to shift the bottleneck in molecular innovation from synthesis to imagination, and thereby help drive a new industrial revolution on the molecular scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.