ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2018
The familial aggregation of atopic diseases and depression or anxiety in children.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- The prevalence of comorbid mental health difficulties in young people with chronic skin conditions: A systematic review and meta-analysis.Journal of health psychology · 2025Pooled it
- Eczema is a shared risk factor for anxiety and depression: A meta-analysis and systematic review.PloS one · 2022Pooled it
- Are prenatal anxiety or depression symptoms associated with asthma or atopic diseases throughout the offspring's childhood? An updated systematic review and meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study.BMC medicine · 2025Article
- Mental health risks in children with food allergies: a population-based comparison of food allergies with other chronic conditions.European journal of pediatrics · 2025Article
- Food Allergy and Mental Health in Children and Adolescents-The Role of Shared Familial Environment.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Internet-delivered cognitive-behaviour therapy for anxiety related to asthma: study protocol for a randomised controlled trial.BMJ open respiratory research · 2024Article
- Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK.BMC medicine · 2023Article
- Paediatric asthma and non-allergic comorbidities: A review of current risk and proposed mechanisms.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Anxiety and depression in adolescents with asthma: a study in clinical practice.Acta bio-medica : Atenei Parmensis · 2022Article
- Sexual Dysfunction and Atopic Dermatitis: A Systematic Review.Life (Basel, Switzerland) · 2021Review
- Anxiety disorders and asthma among adolescents in Uganda: role of early-life exposures.ERJ open research · 2021Article
- Economic burden of peanut allergy in pediatric patients with evidence of reactions to peanuts in the United States.Journal of managed care & specialty pharmacy · 2021Article
- Characteristics and associated morbidities of young adults with misconceived food allergy: A cross-sectional study.EClinicalMedicine · 2021Article
- Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GAClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Allergic Rhinitis and Depression: Profile and Proposal.Frontiers in psychiatry · 2021Review
- Genetic liability to major depression and risk of childhood asthma.Brain, behavior, and immunity · 2020Article
- Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach.Children (Basel, Switzerland) · 2020Article
- Atopic dermatitis and psychosocial comorbidities - What's new?Allergologie select · 2020Review
- Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases has strong genetic and environmental components; therefore, it seems likely that there is a shared liability rather than causative risk.
objectiveTo investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety.
methodsParticipants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n = 14 197. Current and ever asthma, eczema, hay fever and food allergy were reported by parents. Internalizing disorders were identified using validated questionnaires. Familial co-aggregation analysis compared monozygotic (MZ) twins and same-sex dizygotic (DZ) twins for atopic disease in 1 twin with internalizing disorder in the other to test for genetic liability. Several familial liability candidates were also tested including parental education, recent maternal psychological stress, childhood family trauma and parental country of birth.
resultsFamilial co-aggregation analysis found that if 1 twin had at least 1 current atopic disease the partner twin was at risk of having an internalizing disorder regardless of their own atopic status (adjusted OR 1.22 (95% CI 1.08, 1.37). Similar results were found for each atopic disease ever and current. MZ associations were not higher than DZ associations, suggesting that the liability is not genetic in nature. Including other familial candidates to the models made little difference to effect estimates. CONCLUSIONS AND CLINICAL RELEVANCE: Atopic diseases and depression or anxiety tend to occur together in families; therefore, when treating for 1 disease, the physician should consider comorbidity in both the individual and the individual's siblings. We did not find evidence to support a genetic explanation for comorbidity, and further exploration is needed to disentangle the environmental and epigenetic reasons for familial aggregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.