Evidence map›Paper›PMID 29513146›Full record

ReviewPhysiological reviews2018

The Biology of Regeneration Failure and Success After Spinal Cord Injury.

Amanda Phuong Tran, Philippa Mary Warren, Jerry Silver

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07467850 (Dual Stimulation for Spinal Cord Injury), which is not on this map. Cited by 496 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
496citing papers in PubMed, 5 pooled it
31.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07467850 nacompletednot on this mapstarted 2022, after this paper: background citation

Dual Stimulation for Spinal Cord Injury

TypeinterventionalSponsorSpaulding Rehabilitation HospitalRan2022 to 2024Enrolled8ConditionsSpinal Cord InjuriesArmstsDCS+pDCS, Low-level laser therapy
3 · Its place in the literature

Who cites it

496 citing papers in PubMed, 5 syntheses or guidelines pooled it, 869 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Systematic Review of Peptide CAQK: Properties, Applications, and Outcomes.International journal of molecular sciences · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Arachidonic acid metabolism in spinal cord injury.Journal of advanced research · 2026
    Review
  20. Review

436 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Amanda Phuong TranDepartment of Neurosciences, Case Western Reserve University , Cleveland, Ohio ; and School of Biomedical Sciences, University of Leeds , Leeds , United Kingdom.
Philippa Mary WarrenDepartment of Neurosciences, Case Western Reserve University , Cleveland, Ohio ; and School of Biomedical Sciences, University of Leeds , Leeds , United Kingdom.
Jerry SilverDepartment of Neurosciences, Case Western Reserve University , Cleveland, Ohio ; and School of Biomedical Sciences, University of Leeds , Leeds , United Kingdom.
University of Leeds · GB

Funding

Welcome Trust
6 · The paper itself

Abstract

Since no approved therapies to restore mobility and sensation following spinal cord injury (SCI) currently exist, a better understanding of the cellular and molecular mechanisms following SCI that compromise regeneration or neuroplasticity is needed to develop new strategies to promote axonal regrowth and restore function. Physical trauma to the spinal cord results in vascular disruption that, in turn, causes blood-spinal cord barrier rupture leading to hemorrhage and ischemia, followed by rampant local cell death. As subsequent edema and inflammation occur, neuronal and glial necrosis and apoptosis spread well beyond the initial site of impact, ultimately resolving into a cavity surrounded by glial/fibrotic scarring. The glial scar, which stabilizes the spread of secondary injury, also acts as a chronic, physical, and chemo-entrapping barrier that prevents axonal regeneration. Understanding the formative events in glial scarring helps guide strategies towards the development of potential therapies to enhance axon regeneration and functional recovery at both acute and chronic stages following SCI. This review will also discuss the perineuronal net and how chondroitin sulfate proteoglycans (CSPGs) deposited in both the glial scar and net impede axonal outgrowth at the level of the growth cone. We will end the review with a summary of current CSPG-targeting strategies that help to foster axonal regeneration, neuroplasticity/sprouting, and functional recovery following SCI.

Indexed as

AnimalsAxonsChondroitin Sulfate ProteoglycansHumansNerve RegenerationNeurogliaNeuronsSpinal Cord InjuriesChondroitin Sulfate Proteoglycans

Identifiers

PMID29513146
PMCPMC5966716
OpenAlexW2794351872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.