ArticlePharmaceutical biology2018
In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions.
Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Toxicological Assessment of LN20188, a Botanical Combination of Withania somnifera Root and Abelmoschus esculentus Fruit Extracts.BioMed research international · 2026Article
- An Overview of the Current Scientific Evidence on the Biological Properties ofFoods (Basel, Switzerland) · 2025Review
- D-Mannose Attenuates Ethanol-Induced Gastric Ulcers via Antioxidant Activity Through the HSP90/Nrf2/HO-1 Pathway.Drug design, development and therapy · 2025Article
- Evaluation of Anti-cancer Potential ofProtein and peptide letters · 2025Article
- Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.Food science & nutrition · 2024Review
- Article
- Effectiveness of natural biomaterials in the protection and healing of experimentally induced gastric mucosa Ulcer in rats.Molecular biology reports · 2023Article
- A Review: Pharmacological Activity and Phytochemical Profile ofRSC advances · 2023Review
- Understanding the traditional values and use of okra among pregnant women in western Ethiopia: a qualitative study.BMJ open · 2023Article
- Article
- Supplementation with okra combined or not with exercise training is able to protect the heart of animals with metabolic syndrome.Scientific reports · 2023Article
- Genetic enhancement of okra [Frontiers in plant science · 2023Article
- Identification and Quantification of Flavonoids in Okra (Metabolites · 2022Article
- Antioxidant and antidiabetic activities of a polyphenol rich extract obtained fromFrontiers in nutrition · 2022Article
- Okra (Plants (Basel, Switzerland) · 2021Review
- Okra (Molecules (Basel, Switzerland) · 2021Review
- Gastro-Protective Effects ofAntioxidants (Basel, Switzerland) · 2021Article
- Protective Effect of Red Okra (Veterinary medicine international · 2021Article
- Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats.Food science & nutrition · 2020Article
- Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model.Molecular biology reports · 2020Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextOkra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis.
objectiveIn the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models. MATERIALS AND
methodsWistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que). Following a 60 min period, all the rats were given 1 mL of ethanol (80%). One hour after the administration of ethanol, all groups were sacrificed.
resultsAt 5000 mg/kg, the extract produced (okra) no signs of toxicity in animals. Okra 500, 250, 100, Fam 20 and Que 75 inhibited ulcer formation by 81.0, 67.5, 67.0, 76.3 and 72.4%, respectively. Okra 500 significantly decreased edema, hemorrhage and inflammation scores compared with the ethanol group (p < 0.05). The oxidant levels decreased significantly in the all study groups compared within ethanol group (p < 0.001). Serum β-carotene and retinol levels significantly increased 40.2 and 45.4% in the okra 500 group. In okra 500, 250 and Fam 20 groups, apoptosis significantly decreased (p < 0.001), while okra 500, 250 and Fam 20 groups showed a higher percentage of cell proliferation compared with the ethanol group (p < 0.001). DISCUSSION AND
conclusionsOur in vivo data indicate that okra has a gastroprotective effect against ethanol and could reduce the gastric ulcer as seen from biochemical and histopathological results. We suggest that okra could be a possible therapeutic antiulcer agent.
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