Evidence map›Paper›PMID 29513072›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1.

Tracy Bell, Magali Araujo, Zaiming Luo, James Tomlinson, James Leiper, William J Welch, Christopher S Wilcox

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.Laboratory investigation; a journal of technical methods and pathology · 2021
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Tracy BellDepartment of Natural Sciences, University of Maryland Eastern Shore, Princess Anne, Maryland.
Magali AraujoHypertension Research Center and Division of Nephrology and Hypertension, Georgetown University , Washington, District of Columbia.
Zaiming LuoHypertension Research Center and Division of Nephrology and Hypertension, Georgetown University , Washington, District of Columbia.
James TomlinsonMedical Research Council Clinical Research Center, Royal Postgraduate Medical School and Hammersmith Hospital , London , United Kingdom.
James LeiperInstitute of Cardiovascular and Medical Sciences, University of Glasgow , United Kingdom.
William J WelchHypertension Research Center and Division of Nephrology and Hypertension, Georgetown University , Washington, District of Columbia.
Christopher S WilcoxHypertension Research Center and Division of Nephrology and Hypertension, Georgetown University , Washington, District of Columbia.
Georgetown University · USHypertension Institute · USHammersmith Hospital · GBUniversity of Glasgow · GBUniversity of Maryland Eastern Shore · US

Funding

Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
ADENOSINE RECEPTORS IN THE KIDNEYR01DK072183 · NIDDK · GEORGETOWN UNIVERSITY · PI WELCH, WILLIAM J · 2006 to 2015
$2.7M
Regulation of Renal Function and BP by ThromboxaneR01DK109272 · NIDDK · GEORGETOWN UNIVERSITY · PI WELCH, WILLIAM J, WILCOX, CHRISTOPHER S · 2016 to 2019
$1.4M
Medical Research Council MC_UP_1102/12NHLBI NIH HHS P01 HL068686NIDDK NIH HHS R01 DK072183NIDDK NIH HHS R01 DK109272
6 · The paper itself

Abstract

Nitric oxide prevents hypertension yet enhances proximal tubule Na

Indexed as

Renal ReabsorptionAmidohydrolasesAnimalsArginineEnzyme InhibitorsKidney Tubules, ProximalMaleMice, Inbred C57BLNitric OxideRats, Sprague-DawleyRNA InterferenceAmidohydrolasesArgininedimethylargininaseEnzyme InhibitorsNitric OxideN,N-dimethylarginineN(omega)-(2-methoxyethyl)arginineL-257l-nitromethyl argininemicropuncturenitric oxideproximal tubule

Identifiers

PMID29513072
PMCPMC6087787
OpenAlexW2794258292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.