Evidence map›Paper›PMID 29513043›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid.

José Teixeira, Catarina Oliveira, Fernando Cagide, Ricardo Amorim, Jorge Garrido, Fernanda Borges, Paulo J Oliveira

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

José Teixeiraa CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.ORCID http://orcid.org/0000-0003-0834-5698
Catarina Oliveiraa CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.
Fernando Cagidea CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.
Ricardo Amorima CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.
Jorge Garridoe Department of Chemical Engineering, School of Engineering (ISEP) , Polytechnic Institute of Porto , Porto , Portugal.
Fernanda Borgesa CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.ORCID http://orcid.org/0000-0003-1050-2402
Paulo J Oliveirab Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech , Cantanhede , Portugal.ORCID http://orcid.org/0000-0002-5201-9948
Universidade do Porto · PTPolytechnic Institute of Porto · PTUniversity of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacological interventions targeting mitochondria present several barriers for a complete efficacy. Therefore, a new mitochondriotropic antioxidant (AntiOxBEN

Indexed as

Drug DiscoveryAnimalsAntioxidantsCells, CulturedCell SurvivalDose-Response Relationship, DrugGallic AcidHep G2 CellsHumansMaleMitochondria, LiverMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMolecular StructureRatsRats, WistarAntioxidantsGallic AcidMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreGallic acidmitochondrial dysfunctionmitochondrial permeability transition poremitochondriotropic antioxidantoxidative stress

Identifiers

PMID29513043
PMCPMC6010063
OpenAlexW2791894663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.