Evidence map›Paper›PMID 29512893›Full record

Observational studyPediatric pulmonology2018

Outcome evaluation of a pharmacy-based therapy management program for patients with cystic fibrosis.

Heather S Kirkham, Francis Staskon, Nishita Hira, Darren McLane, Karl M Kilgore, Alexis Parente, Seung Kim, Gregory S Sawicki

Abstract readObservational Study
In one paragraph

Observational study in Pediatric pulmonology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Using A Work System Framework to Investigate Pharmacists' Roles in Cystic Fibrosis Management.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heather S KirkhamWalgreen Co., Deerfield, Illinois.ORCID 0000-0003-1247-1005
Francis StaskonWalgreen Co., Deerfield, Illinois.
Nishita HiraAllianceRx Walgreens Prime, Pittsburgh, Pennsylvania.
Darren McLaneAllianceRx Walgreens Prime, Pittsburgh, Pennsylvania.
Karl M KilgoreAvalere Health-an Inovalon Company, Bowie, Maryland.
Alexis ParenteAvalere Health-an Inovalon Company, Bowie, Maryland.
Seung KimAvalere Health-an Inovalon Company, Bowie, Maryland.
Gregory S SawickiBoston Children's Hospital, Boston, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare medication adherence, pulmonary exacerbations, healthcare utilization, and costs for patients with cystic fibrosis (CF) who utilized a pharmacy-based therapy management program to a matched control group. We hypothesized that patient management services would be associated with better medication adherence, and thus require fewer visits to the emergency room or hospitalizations.

methodsThis retrospective, observational cohort study used claims data from the MORE

resultsOf the 236 intervention and 724 control patients meeting selection criteria, 202 were propensity-matched from each cohort. Relative to the control cohort, program patients had 23% higher mean PDC for tobramycin (IRR = 1.23, P = 0.01) and were twice as likely to be adherent to tobramycin (PDC ≥ 80%) than matched controls (OR = 2.14, P = 0.04). Program patients had fewer ER visits (IRR = 0.52, P < 0.01) and slightly lower ER costs (IRR = 0.66, P = 0.06) than the control patients.

conclusionA pharmacy-based therapy management program for CF patients was associated with higher adherence to inhaled tobramycin and lower ER rates. Pharmacies that provide therapy management can support effective CF care management.

Indexed as

Medication Therapy ManagementAdolescentAdultChildCystic FibrosisDeoxyribonuclease IFemaleHumansMaleMedication AdherenceMiddle AgedPharmaciesRecombinant ProteinsYoung AdultDeoxyribonuclease Idornase alfaRecombinant Proteinscosts and cost analysiscystic fibrosismedication adherencepharmacyprogram evaluation

Identifiers

PMID29512893
PMCPMC6001460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.