ArticleEuropean journal of neurology2018
Re-emergent tremor in Parkinson's disease: the effect of dopaminergic treatment.
Article in European journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Non-Invasive Transcutaneous Afferent Patterned Stimulation Therapy Offers Action Tremor Relief in Parkinson's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Trial
- Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.Seminars in neurology · 2026Review
- The evolution of tremor in Parkinson's Disease: insights from a 4-year longitudinal assessment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Association of motor subtype and tremor type with Parkinson's disease progression: An exploratory longitudinal analysis.Journal of Parkinson's disease · 2025Article
- Reconstructing Re-emergent Tremor.Movement disorders clinical practice · 2023Article
- Distal Upper Limb Tremor during Walking in Parkinson's Disease.Movement disorders clinical practice · 2023Article
- Pharmacological Treatment of Tremor in Parkinson's Disease Revisited.Journal of Parkinson's disease · 2023Review
- Clinical neurophysiology of Parkinson's disease and parkinsonism.Clinical neurophysiology practice · 2022Review
- The Molecular Neuroimaging of Tremor.Current neurology and neuroscience reports · 2021Review
- Cerebello-Cortical Control of Tremor Rhythm and Amplitude in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Evolving concepts on bradykinesia.Brain : a journal of neurology · 2020Review
- Pseudo-orthostatic tremor in idiopathic Parkinson's disease: could it be re-emergent tremor?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Erratum.European journal of neurology · 2018Article
Corrections and comments
- Erratum issuedErratum.2018
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatients with Parkinson's disease (PD) with resting tremor may be affected by a tremor that appears after a varying latency while a posture is maintained, a phenomenon referred to as re-emergent tremor (RET). The aim of the study was to evaluate the occurrence and clinical features of RET in patients with PD tested off and on treatment, and to compare the effect of dopaminergic treatment on RET with the effect on resting and action tremor.
methodsWe consecutively enrolled 100 patients with PD. Patients were clinically evaluated 24 h after withdrawal of therapy (off-treatment phase) and 60 min after therapy administration (on-treatment phase). We collected the demographic and clinical data of patients with PD. The severity of the disease was assessed by means of the Hoehn and Yahr scale and Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale part III. We evaluated the latency, severity and body side affected both off and on treatment in patients with RET.
resultsRe-emergent tremor was present in 24% of the patients with PD off treatment and in 19% of the patients on treatment. Dopaminergic treatment reduced the clinical severity of RET. Dopaminergic treatment increased the number of patients with unilateral RET and reduced the number of those who had bilateral RET. RET and resting tremor responded similarly to dopaminergic treatment, whereas action tremor was less responsive. Patients with RET had milder motor symptoms than patients without RET both off and on treatment.
conclusionsDopaminergic treatment modified RET occurrence, severity and body distribution. Dopaminergic depletion plays a role in the pathophysiology of RET.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.