ArticleMolecular medicine reports2018
Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Attention Deficit Hyperactivity Disorder (ADHD) and Polyphenols: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Modulation of Intestinal-Bone Crosstalk by a Standardised Nutraceutical Combination: An In Vitro Mechanistic Study.Nutrients · 2026Article
- Glucosinolate Derivatives: Emerging Anti-Inflammatory Agents.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Glucosinolate Metabolites and Brain Health: An Updated Review on Their Potential Benefits in Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Effects of Lebanese Folk Herbs on Adult Male Rats: Hepatic and Renal Toxicity, Histological, and Biochemical Studies.Nutrients · 2025Article
- Oilseed Cakes: A Promising Source of Antioxidant, and Anti-Inflammatory Agents-Insights fromInternational journal of molecular sciences · 2024Article
- Nutrient utilization, growth performance, and antioxidative status of Barki lambs fed diets supplemented with black (Nigella sativa) and rocket (Eruca sativa) seeds.Tropical animal health and production · 2024Article
- Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells.PloS one · 2024Article
- Dietary glucosinolates derived isothiocyanates: chemical properties, metabolism and their potential in prevention of Alzheimer's disease.Frontiers in pharmacology · 2023Review
- Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide.Phytotherapy research : PTR · 2022Article
- Quantifying Temperature and Osmotic Stress Impact on Seed Germination Rate and Seedling Growth ofLife (Basel, Switzerland) · 2022Article
- Beneficial Effects ofFoods (Basel, Switzerland) · 2022Article
- Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2022Review
- Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats.Environmental science and pollution research international · 2021Article
- Complete chloroplast genome features and phylogenetic analysis of Eruca sativa (Brassicaceae).PloS one · 2021Article
- Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol.Medicina (Kaunas, Lithuania) · 2019Article
- Supercritical CO₂ Extraction ofMolecules (Basel, Switzerland) · 2018Article
- In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Certain nutrients are able to exert health promoting effects. The consumption of Brassicaceae vegetables has increased given their reported beneficial effects on human health, due to their high content of nutraceutical compounds. The health benefits appear to be associated with the presence of glucosinolates and flavonoids. Certain nutraceutics have been revealed to have anti‑inflammatory action. In the present study, the anti‑inflammatory properties of Eruca sativa seed extract (ESE) were evaluated in NSC‑34 motor neurons exposed to the cell culture medium of lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages. Treatment with LPS‑stimulated RAW 264.7 medium induced apoptosis and the expression of Toll‑like receptor 4 (TLR4) and cyclooxygenase 2 (COX2) in NSC‑34 motor neurons. Additionally, the stimulation of NSC‑34 motor neurons with the medium of LPS‑treated macrophages triggered the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome proteins and the production of pro‑inflammatory cytokines. Pre‑treatment with ESE counteracted the apoptosis and production of pro‑inflammatory cytokines in NSC‑34 motor neurons treated with the medium of LPS‑treated RAW 264.7. It also eliminated COX2 and TLR4/NLRP3 inflammasome expression. In addition, pre‑treatment with ESE was able to restore interleukin 10 expression in NSC‑34 cells. These results demonstrate the anti‑inflammatory and neuroprotective effects of ESE.
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