SynthesisBJOG : an international journal of obstetrics and gynaecology2018
Postpartum venous thromboembolism prophylaxis may cause more harm than benefit: a critical analysis of international guidelines through an evidence-based lens.
Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Thromboprophylaxis during pregnancy and the puerperium: a systematic review and economic evaluation to estimate the value of future research.Health technology assessment (Winchester, England) · 2024Pooled it
- Postpartum venous thromboembolism prophylaxis may cause more harm than benefit: a critical analysis of international guidelines through an evidence-based lens.BJOG : an international journal of obstetrics and gynaecology · 2018Pooled it
- Weight-Based Compared With Fixed-Dose Enoxaparin Prophylaxis After Cesarean Delivery: A Randomized Controlled Trial.Obstetrics and gynecology · 2022Trial
- Recommendations from guidelines for the prevention of venous thromboembolism in pregnant women with inherited thrombophilia.Archives of gynecology and obstetrics · 2026Review
- Evaluation of the clinical performance of a risk scoring model for venous thromboembolism prophylaxis in cesarean section for a largely Chinese population.Research and practice in thrombosis and haemostasis · 2026Article
- Pregnancy-Related Venous Thromboembolism Risk Perception and Prevention in Risk-Averse Times-Significant Change Required: a Commentary.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Is early bilateral compression ultrasonography and D-dimer monitoring appropriately for prophylaxis and diagnosis of deep venous thrombosis after cesarean section women: a single-center observation study of Chinese Han population.BMC pregnancy and childbirth · 2024Observational
- Projected impact of guidelines on incidence of venous thromboembolism after cesarean delivery in the United States.Journal of thrombosis and haemostasis : JTH · 2023Article
- Use of the RCOG risk assessment model and biomarkers to evaluate the risk of postpartum venous thromboembolism.Thrombosis journal · 2023Article
- Transperineal pelvic floor ultrasound for assessing posterior pelvic injury and prolapse in postpartum women.American journal of translational research · 2023Article
- Risk stratification for pregnancy-associated venous thromboembolism: Potential role for global coagulation assays.Obstetric medicine · 2022Review
- Prevention and management of venous thromboembolism in pregnancy: cutting through the practice variation.Hematology. American Society of Hematology. Education Program · 2021Article
- Postpartum Heparin Thromboprophylaxis: More Harm Than Good.Obstetrics and gynecology · 2021Article
- Venous thromboembolism incidence among patients recommended for pharmacologic thromboembolism prophylaxis after cesarean delivery in selected guidelines.Journal of thrombosis and haemostasis : JTH · 2021Article
- Developing a model for predicting venous thromboembolism in obese pregnant women in a national study.Thrombosis research · 2020Article
- VTE risk assessment in pregnancy.Research and practice in thrombosis and haemostasis · 2020Article
- Venous thromboembolism prophylaxis may cause more harm than benefit: an evidence-based analysis of Canadian and international guidelines.Thrombosis journal · 2018Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on prediction models and expert opinion, most obstetric venous thromboembolism guidelines recommend low-molecular-weight heparin for many postpartum women, including most delivering by caesarean. Scrutiny reveals major oversights: prediction models are based on studies that report asymptomatic deep vein thrombosis; risk estimates are not adjusted for time exposure; and harm caused by heparin has been overlooked. The benefits of heparin are exaggerated and its harms are under-appreciated. Estimates of the numbers-needed-to-treat and harm are universally lacking. This paper critically reviews the evidence and quantifies the benefit and harm from low-molecular-weight heparin in postpartum women with common risk factors.
fundingThis work was unsponsored and unfunded. TWEETABLE ABSTRACT: Randomised trials should demonstrate more benefit than harm before widespread postpartum low-molecular-weight heparin is recommended.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.