ArticlePhysiological reports2018
Caffeine consumption disrupts hippocampal long-term potentiation in freely behaving rats.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an AScientific reports · 2024Trial
- Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial.Scientific reports · 2023Trial
- Chronic caffeine consumption on clinical TMS outcomes: A naturalistic retrospective analysis.Transcranial magnetic stimulation (2024) · 2025Article
- Short- and long-term neurobehavioural impairments in mice offspring following chronic perinatal caffeine exposure and withdrawal.BMC neuroscience · 2025Article
- Chronic caffeine consumption curbs rTMS-induced plasticity.Frontiers in psychiatry · 2023Article
- Article
- Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage.International journal of molecular sciences · 2022Article
- Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.The Journal of clinical investigation · 2022Article
- Neonatal Seizures and Purinergic Signalling.International journal of molecular sciences · 2020Review
- Effect of caffeinated energy drinks on the structure of hippocampal cornu ammonis 1 and dentate gyrus of adult male albino rats.Anatomy & cell biology · 2020Article
- Caffeine induces neurobehavioral effects through modulating neurotransmitters.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Review
- Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2020Review
- Effect of caffeine on long-term potentiation-like effects induced by quadripulse transcranial magnetic stimulation.Experimental brain research · 2019Article
- Caffeine consumption disrupts hippocampal long-term potentiation in freely behaving rats.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine, one of the most commonly consumed psychoactive substances in the world, has long been known to alter neurological functions, such as alertness, attention, and memory. Despite caffeine's popularity, systematic investigations of its effects on synaptic plasticity in the brain are still lacking. Here we used a freely behaving rodent model of long-term potentiation (LTP), a frequently studied form of synaptic plasticity, to assess the effects of caffeine consumption on hippocampal plasticity. LTP, which is a persistent increase in the strength of synaptic connections between neurons, is a cellular mechanism widely considered to underlie the processes of learning and memory. A group of 10-week-old Sprague-Dawley rats were administered caffeine (1 g/L) in their drinking water 3 weeks prior to collection of electrophysiological data. Another group of age-matched animals received tap water and served as controls. Stimulating and recording electrodes were chronically implanted in the perforant pathway (PP) and dentate gyrus (DG) region of the hippocampus, respectively, to permit stable electrophysiological recordings of synaptic transmission at this synapse. Population spike amplitude (PSA) measures of LTP induction and duration were acquired in vivo while animals were freely behaving using a well-established electrophysiological recording protocol. Results indicate caffeine-treated rats (n = 9) had a significantly (P < 0.05) reduced level of LTP induction compared with controls (n = 10). More studies are needed to identify the exact mechanism through which caffeine alters LTP induction in this freely behaving model of synaptic plasticity.
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