ArticlePhysiological reports2018
Oral contraceptives augment the exercise pressor reflex during isometric handgrip exercise.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Altered Blood Pressure Reflexes in Women With Endometriosis.Hypertension (Dallas, Tex. : 1979) · 2025Trial
- The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness.Physiological reports · 2025Trial
- Oral contraceptives and menstrual cycle influence autonomic reflex function.Physiological reports · 2020Trial
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- The influence of oral contraceptives on the exercise pressor reflex in the upper and lower body.Physiological reports · 2024Article
- The hormonal profile in women using combined monophasic oral contraceptive pills varies across the pill cycle: a temporal analysis of serum endogenous and exogenous hormones using liquid chromatography with tandem mass spectroscopy.American journal of physiology. Endocrinology and metabolism · 2024Article
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Acute cardiac autonomic and haemodynamic responses to leg and arm isometric exercise.European journal of applied physiology · 2022Article
- Menstrual phase does not influence ventilatory responses to group III/IV afferent signaling in eumenorrheic young females.Respiratory physiology & neurobiology · 2021Article
- Sex differences in muscle activity emerge during sustained low-intensity contractions but not during intermittent low-intensity contractions.Physiological reports · 2020Article
- Gender Differences in Hemodynamic Regulation and Cardiovascular Adaptations to Dynamic Exercise.Current cardiology reviews · 2020Review
- Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex.Medicine and science in sports and exercise · 2019Review
- Oral contraceptives augment the exercise pressor reflex during isometric handgrip exercise.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to determine whether oral contraception alters the gender-related differences observed in the exercise pressor reflex during isometric handgrip exercise. Fifteen men, fifteen normally menstruating women (WomenNM), and fifteen women taking monophasic oral contraceptives (WomenOC) completed two trials of a 3-min isometric handgrip exercise protocol performed at 30% of their maximal voluntary contraction: (1) where arterial occlusion was applied to the previously exercising arm during a 3-min recovery period (Occlusion trial); (2) where no arterial occlusion was applied during recovery (Control trial). Handgrip exercise elicited greater increases in mean arterial pressure (MAP) in MEN compared to both female groups (P < 0.05), and in WomenOC compared to WomenNM in both trials (P = 0.01, P = 0.03). After 3 min of recovery, sBP was 12% (P = 0.01) and 9% (P = 0.02) higher in the Occlusion trial when compared to the Control trial for MEN and WomenOC. Conversely, arterial occlusion in recovery from handgrip did not sustain elevated sBP in the Occlusion trial, and sBP returned to recovery levels not different to the Control trial, in WomenNM (P = 0.41). These data indicate that gender-related differences in the metaboreflex during isometric handgrip exercise exist between men and normally menstruating women, but are blunted when men are compared to women taking oral contraceptives. We conclude that the suppression of 17β-estradiol and/or progestogen in women via the administration of oral contraceptives attenuates sex-related differences in the metaboreflex during isometric handgrip exercise.
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