Evidence map›Paper›PMID 29511954›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

25(OH) vitamin D deficiency in lymphoid malignancies, its prevalence and significance. Are we fully aware of it?

Vladislava T Djurasinović, Biljana S Mihaljević, Sandra B Šipetić Grujičić, Svetlana D Ignjatović, Goran Trajković, Milena R Todorović-Balint, Darko A Antić, Jelena S Bila, Boško M Andjelić, Jelena J Jeličić and 3 more

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Vladislava T DjurasinovićClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia. vladislavadj@yahoo.co.uk.ORCID http://orcid.org/0000-0003-0048-0043
Biljana S MihaljevićClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Sandra B Šipetić GrujičićFaculty of Medicine, Institute of Epidemiology, University of Belgrade, Višegradska 26a, Belgrade, Serbia.
Svetlana D IgnjatovićPharmaceutical Faculty, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia.
Goran TrajkovićFaculty of Medicine, Department of Medical Statistics and Informatics, University of Belgrade, Dr Subotica 5, Belgrade, Serbia.
Milena R Todorović-BalintClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Darko A AntićClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Jelena S BilaClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Boško M AndjelićClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Jelena J JeličićClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Vojin M VukovićClinic for Hematology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade, Serbia.
Aleksandra M NikolicFaculty of Medicine, Institute of Epidemiology, University of Belgrade, Višegradska 26a, Belgrade, Serbia.
Stanislaw KlekGeneral Surgery Unit, Stanley Dudrick's Memorial Hospital, 15 Tyniecka Street, 32-050, Skawina, Poland.
University of Belgrade · RS

Funding

This study was supported by the Ministry of Education, Science and Technological Development, Republic of Serbia (Grant No. ON175036 and EP175042). Grant No. ON175036 and EP175042
6 · The paper itself

Abstract

introductionVitamin D has a role in cellular differentiation, proliferation, apoptosis, and angiogenesis and therefore is studied as a prognostic factor in cancer. The aim of our study was to assess the prevalence and significance of 25(OH)D deficiency in patients with lymphoid malignancies. METHODOLOGY: Between January 2014 and June 2016 at the Clinic for Hematology, Clinical Center of Serbia, Belgrade, the pretreatment serum level of 25(OH)D was determined in 133 (62 women/71 men, median age 58 (18-84) years) previously untreated patients with lymphoid malignancy using a chemiluminescent immunoassay. From their medical records, we noted the age, clinical stage, Eastern Cooperative Oncology Group Performance Scale (ECOG PS), nutritional status using the Nutritional Risk Score 2002 (NRS2002), the time of year, comorbidity index, progression, and progression-free survival (PFS) for a median of 20 (1-32) months. The optimal cutoff point for prediction of outcome was determined using the Maximally Selected Rank Statistics.

resultsThere were 37 (27.8%) patients with the severe 25(OH)D deficiency ≤ 25 nmol/l, 80 (60.2%) with 25(OH)D deficiency 25-50 nmol/l, and 16 (12%) with 25(OH)D insufficiency 50-75 nmol/l. None of the patients had the desired normal level. There were significant differences between groups in regard to ECOG PS, NRS2002, type of lymphoma, and progression. The severely 25(OH)D-deficient patients had a shorter mean time until progression (P = 0.018). Cox regression analysis showed that 25(OH)D < 19.6 nmol/l remained the only significant parameter for PFS (HR = 2.921; 95% CI 1.307-6.529).

conclusionThe prevalence of 25(OH)D deficiency in the analyzed group of patients with lymphoid malignancies is high and greater in malnourished individuals. Patients with pretreatment serum 25(OH)D < 19.6 nmol/l had a significantly shorter PFS.

Indexed as

AdolescentAdultAgedAged, 80 and overFemaleHematologic DiseasesHumansLymphocytesMaleMiddle AgedPrevalenceVitamin D DeficiencyYoung Adult25(OH)D levelLymphoma

Identifiers

PMID29511954
OpenAlexW2789864061

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.