Evidence map›Paper›PMID 29511912›Full record

ArticleIrish journal of medical science2019

Single-institution experience with selective internal radiation therapy (SIRT) for the treatment of unresectable colorectal liver metastases.

Cathal O'Leary, Megan Greally, John McCaffrey, Peter Hughes, Leo L P Lawler, Martin O'Connell, Tony Geoghegan, Cormac Farrelly

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Article in Irish journal of medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Radiochemical Feasibility of Mixing ofMolecules (Basel, Switzerland) · 2022
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cathal O'LearyRadiology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
Megan GreallyOncology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
John McCaffreyOncology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
Peter HughesRadiology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
Leo L P LawlerRadiology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
Martin O'ConnellRadiology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
Tony GeogheganRadiology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.
Cormac FarrellyRadiology Department, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland. farrellyc@mater.ie.ORCID http://orcid.org/0000-0003-0120-7209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver metastases are the commonest cause of death for patients with colorectal cancer. Growing evidence supports the use of selective internal radiation therapy (SIRT) in combination with conventional chemotherapy regimens for liver-only or liver-dominant unresectable metastatic colorectal cancer.

aimsTo measure and evaluate outcomes of the first 20 consecutive patients with unresectable colorectal liver metastasis selected for SIRT in addition to their chemotherapy at a single Irish institution.

methodsRetrospective case series was performed. Patient charts and medical records were reviewed.

resultsAll 20 patients (100%) selected for angiographic workup were subsequently successfully treated with radioembolization. All patients were discharged 1 day post-SIRT. At initial imaging evaluation, 12 (60%) had a partial response in their liver, 2 (10%) had stable disease, and 6 (30%) had liver-specific progressive disease. Median follow up was 10 months (range 6-26). At last follow up, 14 (70%) patients were alive and 6 (30%) deceased. Most recent imaging demonstrated 2 (10%) with a complete response, 7 (35%) had a partial response, 2 (10%) had stable disease, and 9 (45%) had progressive disease within their liver. One patient was downstaged to hepatic resection, and one with a complete hepatic response had his primary sigmoid tumor resected 11 months post-SIRT.

conclusionsSIRT is a safe and effective therapy for certain patients with unresectable colorectal liver metastases. This case series supports our opinion that selected patients should be offered SIRT in concert with their medical oncologist, concomitant with their chemotherapy. Larger multi-center studies are required to more clearly define the patient groups that will derive most benefit from SIRT.

Indexed as

AdultAgedAntineoplastic AgentsBrachytherapyChemoradiotherapyColorectal NeoplasmsEmbolization, TherapeuticFemaleHumansLiver NeoplasmsMaleMiddle AgedRetrospective StudiesSurvival RateTreatment OutcomeYttrium RadioisotopesAntineoplastic AgentsYttrium RadioisotopesColorectal liver metastasesCytoreductionInterventional oncologyInterventional radiologyIntra-arterial brachytherapyLocalized therapyMolecular geneticsRadioembolizationRadiosensitizationRadiotherapyRegional therapySIRTUnresectable liver metastases

Identifiers

PMID29511912

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.