ArticlePediatric nephrology (Berlin, Germany)2018
Kidney injury biomarkers 5 years after AKI due to pediatric cardiac surgery.
Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Urinary Biomarkers Of Kidney Function As Predictors Of Cardiovascular Health: A Systematic Review.Current hypertension reports · 2025Pooled it
- Biomarkers for assessing acute kidney injury for people who are being considered for admission to critical care: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2022Pooled it
- Improving pediatric post-acute kidney injury care: considerations for the clinician.Renal failure · 2026Review
- Pediatric acute kidney injury and adverse health outcomes: using a foundational framework to evaluate a causal link.Pediatric nephrology (Berlin, Germany) · 2024Review
- Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury.Science translational medicine · 2023Article
- Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Protein Biomarkers in Chronic Kidney Disease in Children-What Do We Know So Far?Journal of clinical medicine · 2023Review
- The Role of Urinary NGAL in the Management of Primary Vesicoureteral Reflux in Children.International journal of molecular sciences · 2023Review
- Factors Associated With Acute Kidney Injury After Cardiopulmonary Bypass in Children.CJC pediatric and congenital heart disease · 2023Article
- Article
- Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years.Frontiers in pediatrics · 2021Review
- Role of Urinary Beta 2 Microglobulin and Kidney Injury Molecule-1 in Predicting Kidney Function at One Year Following Acute Kidney Injury.International journal of nephrology and renovascular disease · 2021Article
- Pediatric Acute Kidney Injury to the Subsequent CKD Transition.Kidney diseases (Basel, Switzerland) · 2021Review
- Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides.Biomarkers in medicine · 2020Article
- The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Article
- Levels of Proinflammatory Cytokines, Oxidative Stress, and Tissue Damage Markers in Patients with Acute Heart Failure with and without Cardiorenal Syndrome Type 1.Cardiorenal medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundWe previously reported that children undergoing cardiac surgery are at high risk for long-term chronic kidney disease (CKD) and hypertension, although postoperative acute kidney injury (AKI) is not a risk factor for worse long-term kidney outcomes. We report here our evaluation of renal injury biomarkers 5 years after cardiac surgery to determine whether they are associated with postoperative AKI or long-term CKD and hypertension.
methodsChildren aged 1 month to 18 years old undergoing cardiopulmonary bypass were recruited to this prospective cohort study. At 5 years after cardiac surgery, we measured urine interleukin-18, kidney injury molecule-1, monocyte chemoattractant protein-1, YKL-40, and neutrophil gelatinase-associated lipocalin (NGAL). Biomarker levels were compared between patients with AKI and those without. We also performed a cross-sectional analysis of the association between these biomarkers with CKD and hypertension.
resultsOf the 305 subjects who survived hospitalization, four (1.3%) died after discharge, and 110 (36%) participated in the 5-year follow-up. Of these 110 patients, 49 (45%) had AKI. Patients with versus those without postoperative AKI did not have significantly different biomarker concentrations at 5 years after cardiac surgery. None of the biomarker concentrations were associated with CKD or hypertension at 5 years of follow-up, although CKD and hypertension were associated with a higher proportion of participants with abnormal NGAL levels.
conclusionsPostoperative pediatric AKI is not associated with urinary kidney injury biomarkers 5 years after surgery. This may represent a lack of chronic renal injury after AKI, imprecise estimation of the glomerular filtration rate, the need for longer follow-up to detect chronic renal damage, or that our studied biomarkers are inadequate for evaluating subclinical chronic renal injury.
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