Evidence map›Paper›PMID 29511884›Full record

ArticleJournal of cancer research and clinical oncology2018

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma.

Shoko Nakasone, Sachiyo Mimaki, Tomohiro Ichikawa, Keiju Aokage, Tomohiro Miyoshi, Masato Sugano, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Podoplanin in Inflammation and Cancer.International journal of molecular sciences · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Shoko NakasoneDivision of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Sachiyo MimakiDivision of Translational Research, Research Center for Innovate Oncology, National Cancer Center, Kashiwa, Japan.
Tomohiro IchikawaDepartment of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Keiju AokageDepartment of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Tomohiro MiyoshiDepartment of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Masato SuganoDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
Motohiro KojimaDivision of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Satoshi FujiiDivision of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Takeshi KuwataDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
Atsushi OchiaiExploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Masahiro TsuboiDepartment of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Koichi GotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Katsuya TsuchiharaDivision of Translational Research, Research Center for Innovate Oncology, National Cancer Center, Kashiwa, Japan.
Genichiro IshiiDivision of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. gishii@east.ncc.go.jp.ORCID http://orcid.org/0000-0003-4158-0286
National Cancer Center Hospital East · JP

Funding

National Cancer Center Research and Development Fund 25-A-6 and 28-A-9
6 · The paper itself

Abstract

purposePodoplanin-positive cancer-associated fibroblasts (CAFs) play an essential role in tumor progression. However, it is still unclear whether specific genomic alterations of cancer cells are required to recruit podoplanin-positive CAFs. The aim of this study was to investigate the relationship between the mutation status of lung adenocarcinoma cells and the presence of podoplanin-positive CAFs.

methodsNinety-seven lung adenocarcinomas for which whole exome sequencing data were available were enrolled. First, we analyzed the clinicopathological features of the cases, and then, evaluated the relationship between genetic features of cancer cells (major driver mutations and the number of single nucleotide variants, SNVs) and the presence of podoplanin-positive CAFs.

resultsThe presence of podoplanin-positive CAFs was associated with smoking history, solid predominant subtype, and lymph node metastasis. We could not find any significant correlations between major genetic mutations (EGFR, KRAS, TP53, MET, ERBB2, BRAF, and PIC3CA) in cancer cells and the presence of podoplanin-positive CAFs. However, cases with podoplanin-positive CAFs had a significantly higher number of SNVs in cancer cells than the podoplanin-negative CAFs cases (median 84 vs 37, respectively; p = 0.001). This was also detected in a non-smoker subgroup (p = 0.037). Multivariate analyses revealed that the number of SNVs in cancer cells was the only statistically significant independent predictor for the presence of podoplanin-positive CAFs (p = 0.044).

conclusionsIn lung adenocarcinoma, the presence of podoplanin-positive CAFs was associated with higher numbers of SNVs in cancer cells, suggesting a relationship between accumulations of SNVs in cancer cells and the generation of a tumor-promoting microenvironment.

Indexed as

Polymorphism, Single NucleotideAdenocarcinomaAdultAgedAged, 80 and overCancer-Associated FibroblastsExome SequencingFemaleHumansKaplan-Meier EstimateLung NeoplasmsLymphatic MetastasisMaleMembrane GlycoproteinsMiddle AgedMultivariate AnalysisMembrane GlycoproteinsPDPN protein, humanPodoplaninCancer-associated fibroblastsLung adenocarcinomaPodoplaninSingle nucleotide variants

Identifiers

PMID29511884
PMCPMC11813377
OpenAlexW2794252024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.