ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018
Resting state signal latency predicts laterality in pediatric medically refractory temporal lobe epilepsy.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Resting-state functional MRI in pediatric epilepsy: a narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.Brain imaging and behavior · 2023Article
- Reproducibility of cerebral perfusion measurements using BOLD delay.Human brain mapping · 2023Article
- Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.Brain communications · 2023Article
- Automated seizure onset zone locator from resting-state functional MRI in drug-resistant epilepsy.Frontiers in neuroimaging · 2022Article
- A comparison of machine learning classifiers for pediatric epilepsy using resting-state functional MRI latency data.Biomedical reports · 2021Article
- Time-delay structure predicts clinical scores for patients with disorders of consciousness using resting-state fMRI.NeuroImage. Clinical · 2021Article
- Lag Analysis of Fast fMRI Reveals Delayed Information Flow Between the Default Mode and Other Networks in Narcolepsy.Cerebral cortex communications · 2020Article
- The Effect of Scan Length on the Assessment of BOLD Delay in Ischemic Stroke.Frontiers in neurology · 2020Article
- Comparing Cyclicity Analysis With Pre-established Functional Connectivity Methods to Identify Individuals and Subject Groups Using Resting State fMRI.Frontiers in computational neuroscience · 2019Article
- The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD.Frontiers in psychiatry · 2018Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTemporal lobe epilepsy (TLE) affects resting state brain networks in adults. This study aims to correlate resting state functional MRI (rsMRI) signal latency in pediatric TLE patients with their laterality.
methodsFrom 2006 to 2016, 26 surgical TLE patients (12 left, 14 right) with a mean age of 10.7 years (range 0.9-18) were prospectively studied. Preoperative rsMRI was obtained in patients with concordant lateralizing structural MRI, EEG, and PET studies. Standard preprocessing techniques and seed-based rsMRI analyses were performed. Additionally, the latency in rsMRI signal between each 6 mm voxel sampled was examined, compared to the global mean signal, and projected onto standard atlas space for individuals and the cohort.
resultsAll but one of the 26 patients improved seizure frequency postoperatively with a mean follow-up of 2.9 years (range 0-7.7), with 21 patients seizure-free. When grouped for epileptogenic laterality, the latency map qualitatively demonstrated that the right TLE patients had a relatively early signal pattern, whereas the left TLE patients had a relatively late signal pattern compared to the global mean signal in the right temporal lobe. Quantitatively, the two groups had significantly different signal latency clusters in the bilateral temporal lobes (p < 0.001).
conclusionThere are functional MR signal latency changes in medical refractory pediatric TLE patients. Qualitatively, signal latency in the right temporal lobe precedes the mean signal in right TLE patients and is delayed in left TLE patients. With larger confirmatory studies, preoperative rsMRI latency analysis may offer an inexpensive, noninvasive adjunct modality to lateralize pediatric TLE.
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