ArticleNeurobiology of stress2018
Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF serum profiles correlate to different job-stress outcomes.
Article in Neurobiology of stress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Exploring factors associated with inflammation in stressed workers: a cross-sectional study.BMC public health · 2025Article
- Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood.Brain, behavior, & immunity - health · 2025Article
- Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program.Brain, behavior, and immunity · 2025Observational
- Exploring potential causal relationships between gut microbiota, inflammatory factors, and postpartum depression: a Mendelian randomization analysis.BMC pregnancy and childbirth · 2025Article
- Article
- Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program.bioRxiv : the preprint server for biology · 2024Article
- Hair dehydroepiandrosterone sulfate as biomarker of employees' well-being? A longitudinal investigation of support, resilience, and work engagement during COVID-19 pandemic.Frontiers in psychology · 2024Article
- Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion.Nature communications · 2023Article
- Article
- Increased academic stress is associated with decreased plasma BDNF in Chilean college students.PeerJ · 2023Article
- Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?International journal of molecular sciences · 2022Review
- Proteins associated with future suicide attempts in bipolar disorder: A large-scale biomarker discovery study.Molecular psychiatry · 2022Article
- Neuropsychiatric symptoms and seizure related with serum cytokine in epilepsy patients.Scientific reports · 2022Article
- Menthol Flavor in E-Cigarette Vapor Modulates Social Behavior Correlated With Central and Peripheral Changes of Immunometabolic Signalings.Frontiers in molecular neuroscience · 2022Article
- Chemokine profile in women with moderate to severe anxiety and depression during pregnancy.BMC pregnancy and childbirth · 2021Article
- Severity of intervertebral disc herniation regulates cytokine and chemokine levels in patients with chronic radicular back pain.Osteoarthritis and cartilage · 2020Article
- Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1.Molecular medicine reports · 2018Article
- Contribution of diminished kidney transplant GFR to increased circulating chemokine ligand 27 level.Journal of inflammation (London, England) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic psychosocial stress at workplace is an important factor in the development of physical and mental illness. Objective biological measures of chronic stress are still lacking, but inflammatory response and growth factors are increasingly considered as potential stress biomarkers. Therefore, we investigated the relationship between psychophysical strain and serum levels of 48 chemokines, cytokines and growth factors measured using a multiplex immunoassay, and serum brain-derived neurotrophic factor (BDNF) measured by ELISA. Severity of psychophysical strain was scored in 115 healthy hospital workers using specific scales for anxiety, depression-like emotion, gastrointestinal or cardiac disturbances, and ergonomic dysfunction. Multivariate analysis revealed that higher anxiety scale scores were correlated with lower serum chemokine C-C motif ligand-2 (CCL2/MCP-1), chemokine C-C motif ligand-5 (CCL5/RANTES), chemokine C-C motif ligand-27 (CCL27/CTACK), chemokine C-C motif ligand-11 (CCL11/Eotaxin) and interleukin-6 (IL-6); gastrointestinal disturbances correlated with increased levels of interleukin-17 (IL-17) and reduced CCL11/Eotaxin, CCL27/CTACK and CCL2/MCP-1; while cardiac dysfunctions associate only to reduced CCL27/CTACK, and ergonomic dysfunction correlated with increased BDNF and reduced CCL11/Eotaxin and CCL5/RANTES. Thus, these 7 serum factors may provide a distinct signature for each different stress-related psychophysical outcome giving indications on individual vulnerabilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.