ArticleJournal of exercise rehabilitation2018
Treadmill exercise activates PI3K/Akt signaling pathway leading to GSK-3β inhibition in the social isolated rat pups.
Article in Journal of exercise rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium.bioRxiv : the preprint server for biology · 2026Article
- The Inflammation-Energy Metabolism Axis: A Central Driver of Sarcopenia-Osteoporosis: A Narrative Review.Calcified tissue international · 2026Review
- Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise.Journal of neurochemistry · 2025Review
- Exercise-mediated IL-6 downstream effects modulate brain pathology-can exercise training protocols influence the downstream effects?Frontiers in neurology · 2025Review
- Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives.Molecular neurobiology · 2024Review
- Rare A360T Mutation Alters GSK3β(Ser9) Binding in the Cytosolic Loop of Presenilin 1, Influencing β-Catenin Nuclear Localization and Pro-Death Gene Expression in Alzheimer's Disease Case.International journal of molecular sciences · 2023Article
- Association of physical activity with increased PI3K and Akt mRNA levels in adipose tissues of obese and non-obese adults.Scientific reports · 2023Article
- Long-term consequences of COVID-19 on mental health and the impact of a physically active lifestyle: a narrative review.Annals of general psychiatry · 2023Review
- Exercise Training Attenuates Cardiac Vulnerability and Promotes Cardiac Resistance to Isoproterenol-Induced Injury Following Hookah Smoke Inhalation in Male Rats: Role of Klotho and Sirtuins.Cardiovascular toxicology · 2022Article
- Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin.Frontiers in aging neuroscience · 2021Review
- The Role of Irisin and Physical Activity in Breast Cancer.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social isolation is known to precipitate depression-like symptoms in rodents and has emerged as a dependable paradigm to screen the behavioral and neurobiological changes observed in humans. In the present study, the undying mechanisms of treadmill exercise on social isolation-induced depression was evaluated. The rat pups in the social isolation groups were housed individually. The social isolation procedures started on the postnatal day 14. The rat pups in the exercise groups were forced to run on treadmill for 30 min once a day from postnatal day 21 to postnatal day 34. The expression of phosphoinositide 3 kinase (PI3K), tyrosine kinase B (Akt), and glycogen synthase kinase 3β (GSK-3β) in the hippocampus were determined by using western blot analysis. The ratio phosphorylated PI3K (p-PI3K)/PI3K and phosphorylated Akt (p-Akt)/Akt were decreased and the ratio of phosphorylated-GSK-3 (p-GSK-3β)/GSK-3β was increased by social isolation. Treadmill exercise increased the ratio p-PI3K/PI3K and p-Akt/Akt and suppressed the ratio of p-GSK-3β/GSK-3β in the hippocampus of social isolated rat pups. Treadmill exercise activates PI3K/Akt signaling pathway leading to GSK-3β inhibition in social isolated rats. These results suggested that treadmill exercise may improve depressive symptoms via activation of PI3K/Akt signaling pathway.
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