Evidence map›Paper›PMID 29511555›Full record

ArticleUnited European gastroenterology journal2018

Impact of age at diagnosis on disease progression in patients with primary sclerosing cholangitis.

Christian Rupp, Alexander Rössler, Taotao Zhou, Conrad Rauber, Kilian Friedrich, Andreas Wannhoff, Karl-Heinz Weiss, Peter Sauer, Peter Schirmacher, Caner Süsal and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in United European gastroenterology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  6. Sex differences in chronic liver disease and benign liver lesions.JHEP reports : innovation in hepatology · 2023
    Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Christian RuppDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Alexander RösslerDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Taotao ZhouDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Conrad RauberDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Kilian FriedrichDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Andreas WannhoffDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Karl-Heinz WeissDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Peter SauerDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Peter SchirmacherInstitute of Pathology, University of Heidelberg, Heidelberg, Germany.
Caner SüsalDepartment of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.
Wolfgang StremmelDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Daniel N GotthardtDepartment of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe median age of diagnosis of primary sclerosing cholangitis (PSC) is ∼30-40 years.

objectiveWe aimed to analyse disease progression and liver-dependent survival in patients diagnosed with PSC after 50 years of age.

methodsPatients with PSC were analysed with regard to their age at diagnosis. Patients with a first diagnosis of PSC after the age of 50 years were considered as the late-onset group.

resultsA total of 32/215 (14.9%) patients were diagnosed with PSC after 50 years of age. The proportion of females was significantly higher among patients with late-onset PSC (48.4 vs. 27.3%;

conclusionsPatients with later age at diagnosis of PSC displayed a different clinical phenotype with a different sex ratio, immune status and an increased risk for progressive liver failure and biliary malignancies.

Indexed as

cholangiocarcinomadominant stenosisimmunosenescenceinflammatory bowel diseaseliver transplantationPrimary sclerosing cholangitis

Identifiers

PMID29511555
PMCPMC5833225
OpenAlexW2624771279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.