ArticleGastroenterology and hepatology from bed to bench2017
Evaluation of involved proteins in colon adenocarcinoma: an interactome analysis.
Article in Gastroenterology and hepatology from bed to bench, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Combinatorial Network of Transcriptional and miRNA Regulation in Colorectal Cancer.International journal of molecular sciences · 2023Article
- Ontologies and Knowledge Graphs in Oncology Research.Cancers · 2022Review
- Breast Cancer Interaction Network Concept from Mostly Related Components.Galen medical journal · 2019Article
- Human Prolactinoma: A View of Protein-Protein Interaction Pattern.International journal of endocrinology and metabolism · 2018Article
- Barrett's esophagus transits to a cancer condition via potential biomarkers.Gastroenterology and hepatology from bed to bench · 2018Article
- Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study.Galen medical journal · 2018Article
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Authors and funding
5 authors.
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Abstract
aimAssessment of related genes to colon cancer to introduce crucial ones, was the aim of this research.
backgroundColon cancer is one of the invasive colorectal diseases. This disease is preventable and manageable if it be diagnosed in early stage. The aggressive tools for its detection imply more investigation for new molecular diagnostic methods.
methodsNumbers of 300 genes from String database (SD) are analyzed via constructed Protein-protein interaction (PPI) network by Cytoscape software 3.4.0. Based on centrality parameters the main connected component of network was analyzed and the crucial genes were introduced. Cluster analysis of the network and gene ontology for the nodes of the main cluster revealed more details about the role of the key proteins related to colon cancer disease.
resultsThe constructed network was consisted of 300 genes which among them 68 genes were isolated and the 232 other genes formed the main connected component. Ten crucial genes related to colon adenocarcinoma were introduced that presented in cluster 1. Gene ontology analysis showed that cluster 1 is involved in 226 biological processes which are classified in 25 groups.
conclusionIn conclusion, results indicate that the identified key proteins play significant roles in colon adenocarcinoma. It may be possible to introduce a few diagnostic biomarker candidates for colon cancer disease.
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29511483PMC5838192What OpenQuestion holds
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